The accurate segregation of genetic material to daughter cells during mitosis depends on
the precise coordination and regulation of hundreds of proteins by dynamic phosphorylation …

Dynamic protein phosphorylation and dephosphorylation are essential regulatory
mechanisms that ensure proper cellular signaling and biological functions. Deregulation of …

The disassembly of integrin-containing focal adhesions (FAs) at mitotic entry is essential for
cell rounding, mitotic retraction fibre formation, bipolar spindle positioning and chromosome …

In most tissues, anchorage-dependent growth and cell cycle progression are dependent on
cells engaging extracellular matrices (ECMs) via integrin–receptor adhesion complexes. In a …

Regulated start-codon selection has the potential to reshape the proteome through the
differential production of upstream open reading frames, canonical proteins, and alternative …

During interphase, the nuclear envelope (NE) serves as a selective barrier between cytosol
and nucleoplasm. When vertebrate cells enter mitosis, the NE is dismantled in the process of …

Oncogenic KIT or PDGFRA receptor tyrosine kinase mutations are compelling therapeutic
targets in gastrointestinal stromal tumor (GIST), and treatment with the KIT/PDGFRA inhibitor …

Aphidius gifuensis is a parasitoid wasp and primary endoparasitoid enemy of the peach
potato aphid, Myzus persicae. Artificially reared, captive wasps of this species have been …

Molecular programs involved in embryogenesis are frequently upregulated in oncogenic
dedifferentiation and metastasis. However, their precise roles and regulatory mechanisms …

Accurate chromosome segregation requires the perfect spatiotemporal rearrangement of the
cellular cytoskeleton. Isolated more than two decades ago from Drosophila, Aurora A is a …