Angiogenesis, the growth of blood vessels, is a fundamental biological process that controls
embryonic development and is also involved in numerous life-threatening human diseases …

Angiopoietins (ANGPTs) are ligands of the endothelial cell receptor TIE2 and have crucial
roles in the tumour angiogenic switch. Increased expression of ANGPT2 relative to ANGPT1 …

The number of available breast cancer cell (BCC) lines is small, and only a very few of them
have been extensively studied. Whether they are representative of the tumours from which …

Tumor angiogenesis is a key event that governs tumor progression and metastasis. It is
controlled by the complicated and coordinated actions of pro-angiogenic factors and their …

Cells cultured within a three-dimensional (3D) in vitro environment have the ability to
acquire phenotypes and respond to stimuli analogous to in vivo biological systems. This …

Abstracts The Angiopoietin/Tie system acts as a vascular specific ligand/receptor system to
control endothelial cell survival and vascular maturation. The Angiopoietin family includes …

Formation of new blood vessels (angiogenesis) has been demonstrated to be a basic
prerequisite for sustainable growth and proliferation of tumor. Several growth factors …

Angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) have complex actions in angiogenesis
and vascular remodeling due to their effects on Tie2 receptor signaling. Ang2 blocks Ang1 …

Hepatocellular carcinoma (HCC) is becoming one of the most common malignant tumors
worldwide and is characterized by a high vascularity. Angiogenesis, formation of new …

On first view, the literature pertaining to the expression of the angiopoietins in tumours is
confusing and does not readily offer a consensus pattern. Apparently conflicting publications …