Physical stability of amorphous pharmaceutical solids: Nucleation, crystal growth, phase separation and effects of the polymers
Q Shi, F Li, S Yeh, Y Wang, J ** amorphous drug
formulations. Recently, atomic layer coatings (ALCs) of aluminum oxide demonstrated …
formulations. Recently, atomic layer coatings (ALCs) of aluminum oxide demonstrated …
Particle engineering at the drug substance, drug product interface: a comprehensive platform approach to enabling continuous drug substance to drug product …
Direct compression offers a simple route to generate pharmaceutical dosage units and is
core to the growing arena of continuous manufacturing. However, direct compression can be …
core to the growing arena of continuous manufacturing. However, direct compression can be …
Polymer nanocoating of amorphous drugs for improving stability, dissolution, powder flow, and tabletability: the case of chitosan-coated indomethacin
As a result of its higher molecular mobility, the surface of an amorphous drug can grow
crystals much more rapidly than the bulk, causing poor stability and slow dissolution of drug …
crystals much more rapidly than the bulk, causing poor stability and slow dissolution of drug …
Surface nanocoating of high drug-loading spray-dried amorphous solid dispersions by atomic layer coating: Excellent physical stability under accelerated storage …
Physical instability remains a major concern with amorphous solid dispersions (ASDs). In
addition to bulk crystallization inhibition, another potential strategy to improve the physical …
addition to bulk crystallization inhibition, another potential strategy to improve the physical …
Amorphous drug–polymer salt with high stability under tropical conditions and fast dissolution: the case of clofazimine and poly (acrylic acid)
We report that the stability of amorphous clofazimine (CFZ) against crystallization is vastly
improved by salt formation with a polymer without sacrificing dissolution rate. A simple slurry …
improved by salt formation with a polymer without sacrificing dissolution rate. A simple slurry …
Surface Accelerates Crystal Nucleation: The Case of Molnupiravir
K Sun, P Han, C Yao, Y Zhao, C Zhang… - Crystal Growth & …, 2024 - ACS Publications
Molecules at the liquid/vapor interface have different properties, such as faster mobility and
special packing structure, which can potentially affect crystal nucleation. However, the …
special packing structure, which can potentially affect crystal nucleation. However, the …
Polymorph transformation of solid drugs and inhibiting strategies
Y Feng, H Wang, D Wu, K Chen, N Wang, T Wang… - …, 2024 - pubs.rsc.org
Metastable forms and amorphous forms exhibit higher solubility and dissolution rates
compared to stable crystalline forms, making them viable options for pharmaceuticals with …
compared to stable crystalline forms, making them viable options for pharmaceuticals with …
Qualitative and quantitative characterization of composition heterogeneity on the surface of spray dried amorphous solid dispersion particles by an advanced surface …
Surface composition critically impacts stability (eg, crystallization) and performance (eg,
dissolution) of spray dried amorphous solid dispersion (ASD) formulations; however …
dissolution) of spray dried amorphous solid dispersion (ASD) formulations; however …