Cryopreservation of bioflavonoid-rich plant sources and bioflavonoid-microcapsules: emerging technologies for preserving bioactivity and enhancing nutraceutical …

J **ang, R Mlambo, I Shaw, Y Seid, H Shah, Y He… - Frontiers in …, 2023 - frontiersin.org
Bioflavonoids are natural polyphenolic secondary metabolites that are medicinal. These
compounds possess antitumor, cardioprotective, anti-inflammatory, antimicrobial, antiviral …

[HTML][HTML] Opportunities, obstacles and current challenges of flavonoids for luminal and triple-negative breast cancer therapy

VS Vachetta, M Marder, MF Troncoso… - European Journal of …, 2022 - Elsevier
Flavonoids are a large group of polyphenols with numerous biological effects on cancer
cells. They have been shown to affect proliferation via cell cycle arrest, apoptosis and …

Tailoring the lipid composition of nanoparticles modulates their cellular uptake and affects the viability of triple negative breast cancer cells

H Abumanhal-Masarweh, D da Silva, M Poley… - Journal of controlled …, 2019 - Elsevier
Lipid nanoparticles are used widely as anticancer drug and gene delivery systems.
Internalizing into the target cell is a prerequisite for the proper activity of many …

Design, synthesis, and validation of novel nitrogen-based chalcone analogs against triple negative breast cancer

D Elkhalifa, AB Siddique, M Qusa, FS Cyprian… - European Journal of …, 2020 - Elsevier
Great strides have been made in triple negative breast cancer (TNBC) treatment, which
represents 20% of total predicted annual US breast cancer (BC) cases. Despite the …

Anticancer activity of chalcones and its derivatives: review and in silico studies

FF Leite, NF de Sousa, BHM de Oliveira, GD Duarte… - Molecules, 2023 - mdpi.com
Chalcones are direct precursors in the biosynthesis of flavonoids. They have an α, β-
unsaturated carbonyl system which gives them broad biological properties. Among the …

Epigenetics of triple-negative breast cancer via natural compounds

M Kaleem, M Perwaiz, SM Nur… - Current Medicinal …, 2022 - benthamdirect.com
Triple-negative breast cancer (TNBC) is a highly resistant, lethal, and metastatic sub-division
of breast carcinoma, characterized by the deficiency of estrogen receptor (ER), progesterone …

Microarray data analysis reveals gene expression changes in response to ionizing radiation in MCF7 human breast cancer cells

J Bai, Y Luo, S Zhang - Hereditas, 2020 - Springer
Background The aim of this study was to identify potential therapeutic target genes for breast
cancer (BC) by the investigation of gene expression changes after ionizing radiation (IR) in …

[HTML][HTML] Synthesis and Anticancer Evaluation of O-Alkylated (E)-Chalcone Derivatives: A Focus on Estrogen Receptor Inhibition

AR Al-Ghamdi, WU Ahmed, RI Al-Wabli… - International Journal of …, 2025 - mdpi.com
Cancer remains a leading cause of morbidity and mortality worldwide, highlighting the
urgent need for novel therapeutic agents. This study investigated the synthesis and …

A review of the current status of biological effects of plant-derived therapeutics in breast cancer

S Pachal, H Kumar, R Jain, B Goel… - Molecular Biology …, 2025 - Springer
Phytochemicals are bioactive secondary plant metabolites found in high concentrations in
fruits, grains, and vegetables. Recent studies provide evidence of usage of plant-based diets …

Synthesis, characterization and in silico studies of coumarin-chalcone derivatives and their cytotoxicity activity against breast cancer cells

MS Rahama, M Khairuddean, NZ Ismail… - Journal of Molecular …, 2025 - Elsevier
Breast carcinoma disease is the most common ailment affecting women globally. Despite
relentless efforts by scientists, numerous scientific strategies have been blocked by the …