Background Drug-induced liver injury (DILI) is the most challenging and thought-provoking
liver problem for hepatologists owing to unregulated medication usage in medical practices …

Glaucoma is one of the leading causes of blindness worldwide, and as the proportion of
those over age 40 increases, so will the prevalence of glaucoma. The pathogenesis of …

Determining the genetic architecture of Alzheimer's disease pathologies can enhance
mechanistic understanding and inform precision medicine strategies. Here, we perform a …

Endothelial progenitor cell (EPC)-based stem cell therapy is a promising therapeutic
strategy for vascular diseases. However, continuous in vitro expansion for clinical studies …

Cytochrome P450 (CYP) 1B1 belongs to the superfamily of heme-containing
monooxygenases. Unlike other CYP enzymes, which are highly expressed in the liver …

As a promising therapeutic target for cancer, CYP1B1 is overexpressed in Taxol-resistant
A549 cells; however, its role in drug resistance still remains unclear. Bioinformatic analysis …

Abstract The cytochrome P450 (CYP450) family is crucial for metabolizing drugs and natural
substances. Numerous compounds, such as pharmaceuticals and dietary items, can …

Human cytochrome P450 1B1 (CYP1B1) is an extrahepatic heme-containing
monooxygenase. CYP1B1 contributes to the oxidative metabolism of xenobiotics, drugs, and …

Frontal fibrosing alopecia (FFA) is an increasingly prevalent variant of follicular lichen
planus that affects predominantly postmenopausal women and is characterized by …

Background There is a growing concern that junk food has contributed to the childhood
obesity epidemic. Recently, experimental studies suggested that the aryl hydrocarbon …