Rationale for a multi-factorial approach for the reversal of cognitive decline in Alzheimer's disease and MCI: a review

RV Rao, KG Subramaniam, J Gregory… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a multifactorial, progressive, neurodegenerative disease
typically characterized by memory loss, personality changes, and a decline in overall …

Glial cells in Alzheimer's disease: From neuropathological changes to therapeutic implications

MS Uddin, LW Lim - Ageing research reviews, 2022 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder that usually develops slowly and
progressively worsens over time. Although there has been increasing research interest in …

Neuroinflammation: a potential risk for dementia

MA Ahmad, O Kareem, M Khushtar, M Akbar… - International journal of …, 2022 - mdpi.com
Dementia is a neurodegenerative condition that is considered a major factor contributing to
cognitive decline that reduces independent function. Pathophysiological pathways are not …

[HTML][HTML] Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer's disease

Y Li, J Zhang, J Wan, A Liu, J Sun - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Alzheimer's disease (AD) is an age-related neurodegenerative disease with multiple
predisposing factors and complicated pathogenesis. Aβ peptide is one of the most important …

[HTML][HTML] Melatonin and autophagy in aging-related neurodegenerative diseases

F Luo, AF Sandhu, W Rungratanawanich… - International journal of …, 2020 - mdpi.com
With aging, the nervous system gradually undergoes degeneration. Increased oxidative
stress, endoplasmic reticulum stress, mitochondrial dysfunction, and cell death are …

Molecular Mechanisms of ER Stress and UPR in the Pathogenesis of Alzheimer's Disease

MS Uddin, D Tewari, G Sharma, MT Kabir… - Molecular …, 2020 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disease involving aggregation
of misfolded proteins inside the neuron causing prolonged cellular stress. The …

Circadian and sleep dysfunction in Alzheimer's disease

MS Uddin, D Tewari, A Al Mamun, MT Kabir… - Ageing research …, 2020 - Elsevier
Alzheimer's disease (AD) is a devastating and irreversible cognitive impairment and the
most common type of dementia. Along with progressive cognitive impairment, dysfunction of …

[HTML][HTML] Neurocognitive effects of melatonin treatment in healthy adults and individuals with Alzheimer's disease and insomnia: A systematic review and meta-analysis …

DM Sumsuzzman, J Choi, Y **, Y Hong - Neuroscience & Biobehavioral …, 2021 - Elsevier
Endogenous melatonin levels are inversely associated with age and cognitive deficits.
Although melatonin can improve psychopathological behavior disturbances in clinical trials …

Significance of melatonin in the regulation of circadian rhythms and disease management

KB Megha, A Arathi, S Shikha, R Alka, P Ramya… - Molecular …, 2024 - Springer
Melatonin, the 'hormone of darkness' is a neuronal hormone secreted by the pineal gland
and other extra pineal sites. Responsible for the circadian rhythm and seasonal behaviour of …

[HTML][HTML] Exploring the role of COX-2 in Alzheimer's disease: potential therapeutic implications of COX-2 inhibitors

N Moussa, N Dayoub - Saudi Pharmaceutical Journal, 2023 - Elsevier
This review highlights the potential role of cyclooxygenase-2 enzyme (COX-2) in the
pathogenesis of Alzheimer's disease (AD) and the potential therapeutic use of non-steroidal …