Chronic complications of diabetes are due to myriad disorders of numerous metabolic
pathways that are responsible for most of the morbidity and mortality associated with the …

Many types of kidney injury induce inflammation as a protective response. However,
unresolved inflammation promotes progressive renal fibrosis, which can culminate in end …

The gastrointestinal tract—the largest endocrine network in human physiology—
orchestrates signals from the external environment to maintain neural and hormonal control …

Diabetic nephropathy (DN) is a major cause of end-stage renal disease, and therapeutic
options for preventing its progression are limited. To identify novel therapeutic strategies, we …

Diabetic kidney disease (DKD) is a long-term and serious complication of diabetes that
affects millions of people worldwide. It is characterized by proteinuria, glomerular damage …

Oxidative stress is an essential component in the progression of diabetic kidney disease
(DKD), and the transcription factor NF-E2-related factor-2 (Nrf2) plays critical roles in …

Renal fibrosis is a common characteristic of chronic kidney disease (CKD). Aberrant and
excessive depositions of extracellular matrix (ECM) proteins in both glomeruli and interstitial …

Protein-coding genetic variants that strongly affect disease risk can yield relevant clues to
disease pathogenesis. Here we report exome-sequencing analyses of 20,791 individuals …

Diabetic nephropathy is a major cause of ESRD worldwide. Despite its prevalence, a lack of
reliable animal models that mimic human disease has delayed the identification of specific …

Diabetic nephropathy is the most common cause of end-stage renal disease. Therefore,
novel therapies for the suppression of diabetic nephropathy must be developed. Rodent …