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Structure simplification of natural products as a lead generation approach in agrochemical discovery
Natural products (NPs) have a long history as sources of compounds for crop protection.
Perhaps a more important role for NPs has been as models and inspiration for the discovery …
Perhaps a more important role for NPs has been as models and inspiration for the discovery …
A survey of C–C bond formation strategies and mechanism deployed by iron-containing enzymes in natural products
Develo** effective carbon-carbon bond forming strategies is one of the central topics for
organic chemistry, boosting the development of synthetic methods towards complex …
organic chemistry, boosting the development of synthetic methods towards complex …
Beyond the cyclopropyl ring formation: fungal Aj_EasH catalyzes asymmetric hydroxylation of ergot alkaloids
C An, F Zhu, Y Yao, K Zhang, W Wang, J Zhang… - Applied Microbiology …, 2022 - Springer
Ergot alkaloids (EAs) are among the most important bioactive natural products. FeII/α-
ketoglutarate-dependent dioxygenase Aj_EasH from Aspergillus japonicus is responsible …
ketoglutarate-dependent dioxygenase Aj_EasH from Aspergillus japonicus is responsible …
Two Satellite Gene Clusters Enhance Ergot Alkaloid Biosynthesis Capacity of Aspergillus leporis
KA Davis, AM Jones… - Applied and Environmental …, 2023 - journals.asm.org
Ergot alkaloids are fungal specialized metabolites that are important in agriculture and serve
as sources of several pharmaceuticals. Aspergillus leporis is a soil saprotroph that …
as sources of several pharmaceuticals. Aspergillus leporis is a soil saprotroph that …