In recent years, exceptional technological advances have enabled the identification and
interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading …

The metabolic syndrome is prevalent in developed nations and accounts for the largest
burden of non-communicable diseases worldwide. The metabolic syndrome has direct …

The view that sleep is essential for survival is supported by the ubiquity of this behavior, the
apparent existence of sleep-like states in the earliest animals, and the fact that severe sleep …

Sleep plays a vital role in brain function and systemic physiology across many body
systems. Problems with sleep are widely prevalent and include deficits in quantity and …

Humans, like all mammals, partition their daily behaviour into activity (wakefulness) and rest
(sleep) phases that differ largely in their metabolic requirements. The circadian clock …

Molecular clocks are present in almost every cell to anticipate daily recurring and
predictable changes, such as rhythmic nutrient availability, and to adapt cellular functions …

The “fourth industrial revolution”(FIR) is an age of advanced technology based on
information and communication. FIR has a more powerful impact on the economy than in the …

Abstract Exposure to Artificial Light At Night (ALAN) results in a disruption of the circadian
system, which is deleterious to health. In industrialized countries, 75% of the total workforce …

The circadian rhythm is an evolutionarily conserved time-kee** system that comprises a
wide variety of processes including sleep–wake cycles, eating–fasting cycles, and activity …

Epidemiological studies provided the first evidence suggesting a connection between the
circadian clock and human health. Mutant mice convincingly demonstrate the principle that …