Macrophage polarization and metabolism in atherosclerosis

P Hou, J Fang, Z Liu, Y Shi, M Agostini… - Cell death & …, 2023 - nature.com
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of fatty
deposits in the inner walls of vessels. These plaques restrict blood flow and lead to …

Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?

SE Engelen, AJB Robinson, YX Zurke… - Nature Reviews …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …

Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets

R Chen, H Zhang, B Tang, Y Luo, Y Yang… - Signal transduction and …, 2024 - nature.com
The immune response holds a pivotal role in cardiovascular disease development. As
multifunctional cells of the innate immune system, macrophages play an essential role in …

How the immune system shapes atherosclerosis: roles of innate and adaptive immunity

P Roy, M Orecchioni, K Ley - Nature Reviews Immunology, 2022 - nature.com
Atherosclerosis is the root cause of many cardiovascular diseases. Extensive research in
preclinical models and emerging evidence in humans have established the crucial roles of …

Resolvin D1 delivery to lesional macrophages using antioxidative black phosphorus nanosheets for atherosclerosis treatment

Z He, W Chen, K Hu, Y Luo, W Zeng, X He, T Li… - Nature …, 2024 - nature.com
The buildup of plaques in atherosclerosis leads to cardiovascular events, with chronic
unresolved inflammation and overproduction of reactive oxygen species (ROS) being major …

Metabolism of tissue macrophages in homeostasis and pathology

SK Wculek, G Dunphy, I Heras-Murillo… - Cellular & molecular …, 2022 - nature.com
Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

Foam cells in atherosclerosis: novel insights into its origins, consequences, and molecular mechanisms

Y Gui, H Zheng, RY Cao - Frontiers in cardiovascular medicine, 2022 - frontiersin.org
Foam cells play a vital role in the initiation and development of atherosclerosis. This review
aims to summarize the novel insights into the origins, consequences, and molecular …

T cell subsets and functions in atherosclerosis

R Saigusa, H Winkels, K Ley - Nature Reviews Cardiology, 2020 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall and the primary
underlying cause of cardiovascular disease. Data from in vivo imaging, cell-lineage tracing …

Human monocyte subsets and phenotypes in major chronic inflammatory diseases

TS Kapellos, L Bonaguro, I Gemünd, N Reusch… - Frontiers in …, 2019 - frontiersin.org
Human monocytes are divided in three major populations; classical (CD14+ CD16−), non-
classical (CD14dimCD16+), and intermediate (CD14+ CD16+). Each of these subsets is …

Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities

M Bäck, A Yurdagul Jr, I Tabas, K Öörni… - Nature Reviews …, 2019 - nature.com
Atherosclerosis is a lipid-driven inflammatory disease of the arterial intima in which the
balance of pro-inflammatory and inflammation-resolving mechanisms dictates the final …