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Metabolites in the regulatory risk assessment of pesticides in the EU
A large majority of chemicals is converted into metabolites through xenobiotic-metabolising
enzymes. Metabolites may present a spectrum of characteristics varying from similar to …
enzymes. Metabolites may present a spectrum of characteristics varying from similar to …
Bioaccumulation and Metabolism of Carbosulfan in Zebrafish (Danio rerio) and the Toxic Effects of Its Metabolites
J Cui, F Wang, J Gao, W Zhai, Z Zhou… - Journal of Agricultural …, 2019 - ACS Publications
Carbosulfan is a carbamate insecticide that has been widely used in agriculture. However,
studies showed that carbosulfan could be highly toxic to aquatic organisms. The metabolism …
studies showed that carbosulfan could be highly toxic to aquatic organisms. The metabolism …
Characterization of human cytochrome P450 induction by pesticides
K Abass, V Lämsä, P Reponen, J Küblbeck… - Toxicology, 2012 - Elsevier
Pesticides are a large group of structurally diverse toxic chemicals. The toxicity may be
modified by cytochrome P450 (CYP) enzyme activity. In the current study, we have …
modified by cytochrome P450 (CYP) enzyme activity. In the current study, we have …
A comparative study on toxicity induced by carbosulfan and malathion in Wistar rat liver and spleen
IEB Dhouib, MM Lasram, A Annabi, N Gharbi… - Pesticide biochemistry …, 2015 - Elsevier
Organophosphorus (OP) and carbamate (CM) pesticides are widely used in agriculture.
These pesticides are highly toxic to humans and their residues in food pose potential threat …
These pesticides are highly toxic to humans and their residues in food pose potential threat …
[HTML][HTML] Toxicological evaluation of acute and sub-chronic ingestion of hydroalcoholic extract of Solanum cernuum Vell. in mice
CCJ Almança, SV Saldanha, DR Sousa… - Journal of …, 2011 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Solanum cernuum Vellozo is a Brazilian shrub
or small tree, restricted to Southwest states of the country. It has been widely used for the …
or small tree, restricted to Southwest states of the country. It has been widely used for the …
HPLC-MS/MS monitoring and health risk assessment of carbosulfan and its metabolites in date palm fruit (Phoenix dactylifera)
R Morsi, K Ghoudi, B Elabyad, Z Kadoura, H Zeidane… - Scientific reports, 2024 - nature.com
This study investigated residual levels of carbosulfan and its metabolites in date palm fruit in
the UAE using HPLC-MS/MS and QuEChERS method. The method demonstrated excellent …
the UAE using HPLC-MS/MS and QuEChERS method. The method demonstrated excellent …
Immunosuppression and oxidative stress induced by subchronic exposure to carbosulfan in rat spleen: immunomodulatory and antioxidant role of N-acetylcysteine
IB Dhouib, MM Lasram, M Abdeladhim… - Toxicology …, 2014 - Taylor & Francis
The present study was designed to determine the immunosuppressive effects of carbosulfan
(CB) and their relationship with an increased formation of reactive oxygen species in rat …
(CB) and their relationship with an increased formation of reactive oxygen species in rat …
Comparative metabolism of benfuracarb in in vitro mammalian hepatic microsomes model and its implications for chemical risk assessment
In vitro metabolism of benfuracarb in liver microsomes from seven species was studied in
order to quantitate species-specific metabolic profiles and enhance benfuracarb risk …
order to quantitate species-specific metabolic profiles and enhance benfuracarb risk …
Metabolism of methiocarb and carbaryl by rat and human livers and plasma, and effect on their PXR, CAR and PPARα activities
C Fu**o, Y Tamura, S Tange, H Nakajima… - The Journal of …, 2016 - jstage.jst.go.jp
The oxidative, reductive, and hydrolytic metabolism of methiocarb and the hydrolytic
metabolism of carbaryl by liver microsomes and plasma of rats or humans were examined …
metabolism of carbaryl by liver microsomes and plasma of rats or humans were examined …
Metabolism of carbosulfan II. Human interindividual variability in its in vitro hepatic biotransformation and the identification of the cytochrome P450 isoforms involved
This study aims to characterize interindividual variability and individual CYP enzymes
involved in the in vitro metabolism of the carbamate insecticide carbosulfan. Microsomes …
involved in the in vitro metabolism of the carbamate insecticide carbosulfan. Microsomes …