Cardiac fibroblasts are the most prevalent cell type in the heart and play a key role in
regulating normal myocardial function and in the adverse myocardial remodeling that occurs …

Interleukin-6 is a pleiotropic cytokine regulating different tissues and organs in diverse and
sometimes discrepant ways. The dual and sometime hermetic nature of IL-6 action has been …

A reciprocal regulation exists between the central nervous and immune systems through
which the CNS signals the immune system via hormonal and neuronal pathways and the …

The inflammatory response is a highly regulated physiological process that is critically
important for homeostasis. A precise physiological control of inflammation allows a timely …

Recent discoveries involving the cytokine interleukin (IL)-6 have originated from diverse
disciplines, revealing roles in biological processes that are likewise varied. The most novel …

Abstract Interleukin-6 (IL-6) is a prototypical cytokine with functional pleiotropy and plays an
important role in host defense. When infections or tissue injuries occur, IL-6 is promptly …

IL6 is a multifunctional cytokine with pivotal roles in the inflammatory response and in
directing T cell differentiation in adaptive immunity. IL6 is widely expressed in the female …

Nuclear factor κB (NF‐κB) is one of the key regulators of transcription of a variety of genes
involved in immune and inflammatory responses. NF‐κB activity has long been thought to be …

PURPOSE: To determine the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT),
and pharmacodynamics (PD) of the proteasome inhibitor bortezomib (previously known as …

Inflammation and microenvironment play a crucial role in muscle regeneration. IL
(interleukin)-6, as a multifunctional cytokine is involved in the processes. However, the …