CRISPR–Cas systems provide resistance against foreign mobile genetic elements and have
a wide range of genome editing and biotechnological applications. In this Review, we …

CRISPR-Cas, the bacterial and archaeal adaptive immunity systems, encompass a complex
machinery that integrates fragments of foreign nucleic acids, mostly from mobile genetic …

Many bacteria and archaea have the unique ability to heritably alter their genomes by
incorporating small fragments of foreign DNA, called spacers, into CRISPR loci. Once …

Although dynamics underlie many biological processes, our ability to robustly and
accurately profile time-varying biological signals and regulatory programs remains limited …

Measuring biological data across time and space is critical for understanding complex
biological processes and for various biosurveillance applications. However, such data are …

DNA has been the predominant information storage medium for biology and holds great
promise as a next-generation high-density data medium in the digital era. Currently, the vast …

Abstract The Clustered Regularly Interspaced Palindromic Repeats (CRISPR)-CRISPR-
associated proteins (Cas) systems of bacterial and archaeal adaptive immunity show …

The CRISPR–Cas genome editing system is an intrinsic property of a bacteria-based
immune system. This employs a guide RNA to detect and cleave the PAM-associated target …

Clustered regularly interspaced short palindromic repeats (CRISPR)–Cas systems provide
protection against viral and plasmid infection by capturing short DNA sequences from these …

Prokaryotic organisms have developed multiple defense systems against phages; however,
little is known about whether and how these interact with each other. Here, we studied the …