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PIWI-interacting RNA: its biogenesis and functions
PIWI-interacting RNAs (piRNAs) are a class of small RNAs that are 24–31 nucleotides in
length. They associate with PIWI proteins, which constitute a germline-specific subclade of …
length. They associate with PIWI proteins, which constitute a germline-specific subclade of …
PIWI proteins and PIWI-interacting RNAs in the soma
RJ Ross, MM Weiner, H Lin - Nature, 2014 - nature.com
The discovery of millions of PIWI-interacting RNAs revealed a fascinating and unanticipated
dimension of biology. The PIWI–piRNA pathway has been commonly perceived as germline …
dimension of biology. The PIWI–piRNA pathway has been commonly perceived as germline …
Small RNAs are trafficked from the epididymis to develo** mammalian sperm
The biogenesis of the RNA payload of mature sperm is of great interest, because RNAs
delivered to the zygote at fertilization can affect early development. Here, we tested the …
delivered to the zygote at fertilization can affect early development. Here, we tested the …
Non-model model organisms
Abstract Model organisms are widely used in research as accessible and convenient
systems to study a particular area or question in biology. Traditionally only a handful of …
systems to study a particular area or question in biology. Traditionally only a handful of …
PIWI-interacting RNAs: from generation to transgenerational epigenetics
Small-RNA-guided gene regulation is a recurring theme in biology. Animal germ cells are
characterized by an intriguing small-RNA-mediated gene-silencing mechanism known as …
characterized by an intriguing small-RNA-mediated gene-silencing mechanism known as …
The expanding implications of polyploidy
Polyploid cells, which contain more than two genome copies, occur throughout nature.
Beyond well-established roles in increasing cell size/metabolic output, polyploidy can also …
Beyond well-established roles in increasing cell size/metabolic output, polyploidy can also …
Soma-to-germline RNA communication
More than a century ago, August Weissman defined a distinction between the germline
(responsible for propagating heritable information from generation to generation) and the …
(responsible for propagating heritable information from generation to generation) and the …
Principles of transgenerational small RNA inheritance in Caenorhabditis elegans
Examples of transgenerational inheritance of environmental responses are rapidly
accumulating. In Caenorhabditis elegans nematodes, such heritable information transmits …
accumulating. In Caenorhabditis elegans nematodes, such heritable information transmits …
PIWI proteins and PIWI-interacting RNA: emerging roles in cancer
P-Element induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a type of noncoding
RNAs (ncRNAs) and interact with PIWI proteins. piRNAs were primarily described in the …
RNAs (ncRNAs) and interact with PIWI proteins. piRNAs were primarily described in the …
Delete and survive: strategies of programmed genetic material elimination in eukaryotes
Genome stability is a crucial feature of eukaryotic organisms because its alteration
drastically affects the normal development and survival of cells and the organism as a …
drastically affects the normal development and survival of cells and the organism as a …