Cyclooxygenase (COX) enzymes comprise COX-1 and COX-2 isoforms and are responsible
for prostaglandin production. Prostaglandins have critical roles in the inflammation pathway …

Curcumin is a compound isolated from turmeric, a plant known for its medicinal use.
Recently, there is a growing interest in the medical community in identifying novel, low-cost …

The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear,
preventing effective therapeutics development. Here, we report a proteomic analysis of 144 …

Computationally identifying new targets for existing drugs has drawn much attention in drug
repurposing due to its advantages over de novo drugs, including low risk, low costs, and …

Enzymatically oxidized lipids are a specific group of biomolecules that function as key
signaling mediators and hormones, regulating various cellular and physiological processes …

After more than a century, aspirin remains one of the most commonly used drugs in western
medicine. Although mainly used for its anti-thrombotic, anti-pyretic, and analgesic properties …

Cyclooxgenases are key enzymes of lipid signaling. They carry out the first step in the
production of prostaglandins, important mediators of inflammation, pain, cardiovascular …

Inflammatory mediators of the arachidonic acid cascade from cyclooxygenase (COX) and
lipoxygenase (LOX) pathways are primarily responsible for many diseases in human beings …

Cyclooxygenase-2 (COX-2) catalyzes the oxygenation of arachidonic acid (AA) and
endocannabinoid substrates, placing the enzyme at a unique junction between the …

COX-2, a key enzyme that catalyzed the rate-limiting steps in the conversion of arachidonic
acid to prostaglandins, played a pivotal role in the inflammatory process. Different from other …