Computational analysis of RNA sequences constitutes a crucial step in the field of RNA
biology. As in other domains of the life sciences, the incorporation of artificial intelligence …

Although fragment-based drug discovery (FBDD) has been successfully implemented and
well-explored for protein targets, its feasibility for RNA targets is emerging. Despite the …

RNA is challenging to target with bioactive small molecules, particularly those of low
molecular weight that bind with sufficient affinity and specificity. In this report, we developed …

Rapid development within the fields of both fragment‐based drug discovery (FBDD) and
medicinal targeting of RNA provides possibilities for combining technologies and methods in …

In the era of data science, data-driven algorithms have emerged as powerful platforms that
can consolidate bioisosteric rules for preferential modifications on small molecules with a …

Ribosomes, which synthesize proteins, are critical organelles for the survival and growth of
bacteria. About 60% of approved antibiotics discovered so far combat pathogenic bacteria …

Thiazoles exhibit a wide range of biological activities and therefore represent useful and
attractive building blocks. To evaluate their usefulness and pinpoint their liabilities in …

Mycobacterium tuberculosis is the causative agent of TB and was estimated to cause 1.4
million death in 2019, alongside 10 million new infections. Drug resistance is a growing …

Fluorogenic RNAs such as the Mango aptamers are uniquely powerful tools for imaging
RNA. A central challenge has been to develop brighter, more specific, and higher affinity …

We report that a selective fluorescent indicator NBD-NCD for UGGAA repeats resulted in
fluorescence quenching upon binding to RNA and recovered the fluorescence by displacing …