Natural killer (NK) cells have crucial roles in the innate immunosurveillance of cancer and
viral infections. They are 'first responders' that can spontaneously recognize abnormal cells …

In recent decades, immune checkpoint blockade and chimeric antigen receptor T cell (CAR-
T) therapy are two milestone achievements in clinical immunotherapy. However, both show …

NK cells play important roles in innate defenses against viruses and in the control of tumor
growth and metastasis. The regulation/induction of NK cell function is mediated by an array …

The Natural Cytotoxicity Receptors (NCRs), NKp46, NKp44, and NKp30, were some of the
first human activating Natural Killer (NK) cell receptors involved in the non-MHC-restricted …

Cells of the innate immunity play an important role in tumor immunotherapy. Thus, NK cells
can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity …

Natural killer (NK) cells are innate lymphoid cells endowed with cytolytic activity and a
capacity to secrete cytokines and chemokines. Several lines of evidence suggest that NK …

Many tumors produce platelet-derived growth factor (PDGF)-DD, which promotes cellular
proliferation, epithelial-mesenchymal transition, stromal reaction, and angiogenesis through …

Targeting highly proliferating cells is an important issue for many types of aggressive tumors.
Proliferating Cell Nuclear Antigen (PCNA) is an essential protein that participates in a variety …

The ability of tumors to manage an immune‐mediated attack has been recently included in
the “next generation” of cancer hallmarks. In solid tumors, the microenvironment that is …

Breast cancer (BC) is the main cause of cancer-related mortality among women globally.
Despite substantial advances in the identification and management of primary tumors …