Mitochondrial electron transport generates the ATP that is essential for the excitability and
survival of neurons, and the protein phosphorylation reactions that mediate synaptic …

Human and animal studies suggest an intriguing link between mitochondrial diseases and
depression. Although depression has historically been linked to alterations in …

Lipid peroxidation is a complex process involving the interaction of oxygen-derived free
radicals with polyunsaturated fatty acids, resulting in a variety of highly reactive electrophilic …

The production of neurons from neural progenitor cells, the growth of axons and dendrites
and the formation and reorganization of synapses are examples of neuroplasticity. These …

The formation, maintenance and reorganization of synapses are critical for brain
development and the responses of neuronal circuits to environmental challenges. Here we …

Newly generated neurons pass through a series of well-defined developmental stages,
which allow them to integrate into existing neuronal circuits. After exit from the cell cycle …

Mitochondria play a critical role in regulating cellular functions including bioenergetics,
calcium homeostasis, redox signalling, and apoptotic cell death. Mitochondria are also …

The mechanisms controlling the post-natal maturation of astrocytes play a crucial role in
ensuring correct synaptogenesis. We show that mitochondrial biogenesis in develo** …

In the develo** and mature brain, mitochondria act as central hubs for distinct but
interwined pathways, necessary for neural development, survival, activity, connectivity and …

Mitochondria are dynamic ATP‐generating organelle which contribute to many cellular
functions including bioenergetics processes, intracellular calcium regulation, alteration of …