The capacity of organisms to sense changes in the levels of internal and external gases and
to respond accordingly is central to a range of physiologic and pathophysiologic processes …

The cellular uptake of many nutrients and micronutrients governs both their cellular
availability and their systemic homeostasis. The cellular rate of nutrient or ion uptake (eg …

The biological effects and physiological consequences of hypercapnia are increasingly
understood. The literature on hypercapnia is confusing, and at times contradictory. On the …

Inflammation, although necessary to fight infections, becomes a threat when it exceeds the
capability of the immune system to control it. In addition, inflammation is a cause and/or …

A significant number of patients with coronavirus disease 2019 (COVID-19) develop acute
respiratory distress syndrome (ARDS) that is associated with a poor outcome. The molecular …

Gases are sensed by lung cells and can activate specific intracellular signalling pathways,
and thus have physiological and pathophysiological effects. Carbon dioxide (CO2), a …

Permissive hypercapnia: what to remember : Current Opinion in Anesthesiology Permissive
hypercapnia: what to remember : Current Opinion in Anesthesiology Log in or Register …

Patients with severe acute and chronic lung diseases develop derangements in gas
exchange that may result in increased levels of CO2 (hypercapnia), the effects of which on …

Persistent symptoms and radiographic abnormalities suggestive of failed lung repair are
among the most common symptoms in patients with COVID-19 after hospital discharge. In …

Disruption of the alveolar–capillary barrier and accumulation of pulmonary edema, if not
resolved, result in poor alveolar gas exchange leading to hypoxia and hypercapnia, which …