Since its discovery as a primary component in cytoplasmic aggregates in post-mortem tissue
of patients with Amyotrophic Lateral Sclerosis (ALS), TAR DNA Binding Protein 43 kDa (TDP …

Calcium (Ca2+) functions as a second messenger that is critical in regulating fundamental
physiological functions such as cell growth/development, cell survival, neuronal …

The ubiquitin–proteasome system (UPS) and autophagy are two distinct and interacting
proteolytic systems. They play critical roles in cell survival under normal conditions and …

ABSTRACT SQSTM1 (also known as p62) is a multifunctional stress-inducible scaffold
protein involved in diverse cellular processes. Its functions are tightly regulated through an …

The p62 protein, also called sequestosome 1 (SQSTM1), is a ubiquitin‐binding scaffold
protein that colocalizes with ubiquitinated protein aggregates in many neurodegenerative …

Cap'n'collar (Cnc) transcription factors are conserved in metazoans and have important
developmental and homeostatic functions. The vertebrate Nrf1, Nrf2, and Nrf3; the …

Background The SQSTM1 gene encodes p62, a major pathologic protein involved in
neurodegeneration. Objective To examine whether SQSTM1 mutations contribute to familial …

Autophagy is a phylogenetically conserved mechanism that controls the degradation of
subcellular constituents, including misfolded proteins, and damaged organelles. The …

Amyotrophic lateral sclerosis (ALS) is a debilitating motor neuron disease and lacks effective
disease-modifying treatments. This study utilizes a comprehensive multiomic approach to …

The two main routes that cells use for degrading intracellular proteins are the ubiquitin-
proteasome and autophagy-lysosome pathways, which have been thought to have largely …