[HTML][HTML] Recent advances in sensing the inter-biomolecular interactions at the nanoscale–A comprehensive review of AFM-based force spectroscopy

A Lostao, KS Lim, MC Pallarés, A Ptak… - International journal of …, 2023 - Elsevier
Biomolecular interactions underpin most processes inside the cell. Hence, a precise and
quantitative understanding of molecular association and dissociation events is crucial, not …

Substoichiometric action of long noncoding RNAs

JP Unfried, I Ulitsky - Nature cell biology, 2022 - nature.com
Low expression levels and stoichiometric imbalances of long noncoding RNAs (lncRNAs)
are often used as evidence for their probable lack of function or for limiting the scope of their …

Atomic-and molecular-resolution map** of solid–liquid interfaces by 3D atomic force microscopy

T Fukuma, R Garcia - ACS nano, 2018 - ACS Publications
Hydration layers are ubiquitous in life and technology. Hence, interfacial aqueous layers
have a central role in a wide range of phenomena from materials science to molecular and …

Visualizing RNA conformational and architectural heterogeneity in solution

J Ding, YT Lee, Y Bhandari, CD Schwieters… - Nature …, 2023 - nature.com
RNA flexibility is reflected in its heterogeneous conformation. Through direct visualization
using atomic force microscopy (AFM) and the adenosylcobalamin riboswitch aptamer …

[HTML][HTML] Atomic force microscopy—A tool for structural and translational DNA research

KHS Main, JI Provan, PJ Haynes, G Wells… - APL …, 2021 - pubs.aip.org
Atomic force microscopy (AFM) is a powerful imaging technique that allows for structural
characterization of single biomolecules with nanoscale resolution. AFM has a unique …

Determining structures of RNA conformers using AFM and deep neural networks

MFS Degenhardt, HF Degenhardt, YR Bhandari… - Nature, 2024 - nature.com
Much of the human genome is transcribed into RNAs, many of which contain structural
elements that are important for their function. Such RNA molecules—including those that are …

Conserved structures and dynamics in 5′-proximal regions of Betacoronavirus RNA genomes

TR de Moura, E Purta, A Bernat… - Nucleic acids …, 2024 - academic.oup.com
Betacoronaviruses are a genus within the Coronaviridae family of RNA viruses. They are
capable of infecting vertebrates and causing epidemics as well as global pandemics in …

Hydration structure of a single DNA molecule revealed by frequency-modulation atomic force microscopy

K Kuchuk, U Sivan - Nano letters, 2018 - ACS Publications
Hydration interaction shapes biomolecules and is a dominant intermolecular force. Map**
the hydration patterns of biomolecules is therefore essential for understanding molecular …

Advances, Applications, and Perspectives in Small‐Angle X‐ray Scattering of RNA

JN Tants, A Schlundt - Chembiochem, 2023 - Wiley Online Library
RNAs exhibit a plethora of functions far beyond transmitting genetic information. Often, RNA
functions are entailed in their structure, be it as a regulatory switch, protein binding site, or …

Atomic force microscopy 3D structural reconstruction of individual particles in the study of amyloid protein assemblies

C Chitty, K Kuliga, WF Xue - Biochemical Society Transactions, 2024 - portlandpress.com
Recent developments in atomic force microscopy (AFM) image analysis have made three-
dimensional (3D) structural reconstruction of individual particles observed on 2D AFM height …