Why won't it stop? The dynamics of benzodiazepine resistance in status epilepticus

RJ Burman, RE Rosch, JM Wilmshurst, A Sen… - Nature Reviews …, 2022 - nature.com
Status epilepticus is a life-threatening neurological emergency that affects both adults and
children. Approximately 36% of episodes of status epilepticus do not respond to the current …

Ketamine as advanced second‐line treatment in benzodiazepine‐refractory convulsive status epilepticus in children

S Buratti, E Giacheri, A Palmieri, J Tibaldi, G Brisca… - …, 2023 - Wiley Online Library
Status epilepticus (SE) is one of the most common neurological emergencies in children. To
date, there is no definitive evidence to guide treatment of SE refractory to benzodiazepines …

European resuscitation council guidelines 2021: paediatric life support

P Van de Voorde, NM Turner, J Djakow, N de Lucas… - Resuscitation, 2021 - Elsevier
Abstract These European Resuscitation Council Paediatric Life Support (PLS) guidelines,
are based on the 2020 International Consensus on Cardiopulmonary Resuscitation Science …

Lebensrettende Maßnahmen bei Kindern (Paediatric Life Support, PLS)

P Van de Voorde, NM Turner, J Djakow… - Notfall+ …, 2021 - Springer
Zusammenfassung Die Leitlinien des European Resuscitation Council (ERC) zu den
lebensrettenden Maßnahmen bei Kindern (Paediatric Life Support, PLS) basieren auf dem …

Association of time to treatment with short-term outcomes for pediatric patients with refractory convulsive status epilepticus

M Gaínza-Lein, IS Fernández, M Jackson… - JAMA …, 2018 - jamanetwork.com
Importance Treatment delay for seizures can lead to longer seizure duration. Whether
treatment delay is associated with major adverse outcomes, such as death, remains …

Long‐term outcomes of status epilepticus: a critical assessment

C Sculier, M Gaínza‐Lein, I Sánchez Fernández… - …, 2018 - Wiley Online Library
We reviewed 37 studies reporting long‐term outcomes after a status epilepticus (SE)
episode in pediatric and adult populations. Study design, length of follow‐up, outcome …

Misdiagnosis of prolonged psychogenic non-epileptic seizures as status epilepticus: epidemiology and associated risks

J Jungilligens, R Michaelis, S Popkirov - Journal of Neurology …, 2021 - jnnp.bmj.com
Objective To determine the epidemiology of prolonged psychogenic non-epileptic seizures
(pPNES) misdiagnosed as status epilepticus, as well as the risks associated with non …

[HTML][HTML] Pediatric refractory and super-refractory status epilepticus

A Vasquez, R Farias-Moeller, W Tatum - Seizure, 2019 - Elsevier
Purpose To summarize the available evidence related to pediatric refractory status
epilepticus (RSE) and super-refractory status epilepticus (SRSE), with emphasis on …

[HTML][HTML] Pathophysiology of convulsive status epilepticus

IS Fernández, HP Goodkin, RC Scott - Seizure, 2019 - Elsevier
Purpose To summarize the pathophysiology of convulsive status epilepticus (SE) with a
focus on practical implications for treatment. Method Narrative review of the medical …

Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus

RJ Burman, JS Selfe, JH Lee, M van den Berg, A Calin… - Brain, 2019 - academic.oup.com
Status epilepticus is defined as a state of unrelenting seizure activity. Generalized
convulsive status epilepticus is associated with a rapidly rising mortality rate, and thus …