Sharing the SAGA
Transcription initiation is a major regulatory step in eukaryotic gene expression. Co-
activators establish transcriptionally competent promoter architectures and chromatin …
activators establish transcriptionally competent promoter architectures and chromatin …
Dynamic modules of the coactivator SAGA in eukaryotic transcription
Abstract SAGA (Spt-Ada-Gcn5 acetyltransferase) is a highly conserved transcriptional
coactivator that consists of four functionally independent modules. Its two distinct enzymatic …
coactivator that consists of four functionally independent modules. Its two distinct enzymatic …
Ubiquitin-specific peptidase 22 in cancer
T Feng, S Ling, C Xu, L Ying, D Su, X Xu - Cancer letters, 2021 - Elsevier
Recently, many studies have shown that deubiquitination modification of proteins is of great
significance in major physiological processes such as cell proliferation, apoptosis, and …
significance in major physiological processes such as cell proliferation, apoptosis, and …
[HTML][HTML] Characterizing and exploiting the many roles of aberrant H2B monoubiquitination in cancer pathogenesis
LM Jeusset, KJ McManus - Seminars in Cancer Biology, 2022 - Elsevier
Monoubiquitination of histone H2B on lysine 120 (H2Bub1) is implicated in the control of
multiple essential processes, including transcription, DNA damage repair and mitotic …
multiple essential processes, including transcription, DNA damage repair and mitotic …
Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis
Maintaining proteostasis is important for animal development. How proteostasis influences
spermatogenesis that generates male gametes, spermatozoa, is not clear. We show that …
spermatogenesis that generates male gametes, spermatozoa, is not clear. We show that …
Characterization of a metazoan ADA acetyltransferase complex
JHM Soffers, X Li, A Saraf, CW Seidel… - Nucleic Acids …, 2019 - academic.oup.com
The Gcn5 acetyltransferase functions in multiple acetyltransferase complexes in yeast and
metazoans. Yeast Gcn5 is part of the large SAGA (Spt-Ada-Gcn5 acetyltransferase) complex …
metazoans. Yeast Gcn5 is part of the large SAGA (Spt-Ada-Gcn5 acetyltransferase) complex …
Transcription and mRNA export machineries SAGA and TREX-2 maintain monoubiquitinated H2B balance required for DNA repair
FM Evangelista, A Maglott-Roth, M Stierle… - Journal of Cell …, 2018 - rupress.org
DNA repair is critical to maintaining genome integrity, and its dysfunction can cause
accumulation of unresolved damage that leads to genomic instability. The Spt–Ada–Gcn5 …
accumulation of unresolved damage that leads to genomic instability. The Spt–Ada–Gcn5 …
Function and regulation of the Spt-Ada-Gcn5-Acetyltransferase (SAGA) deubiquitinase module
DV Cornelio-Parra, R Goswami, K Costanzo… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Abstract The Spt-Ada-Gcn5 Acetyltransferase (SAGA) chromatin modifying complex is a
critical regulator of gene expression and is highly conserved across species. Subunits of …
critical regulator of gene expression and is highly conserved across species. Subunits of …
The epigenetic machinery in the life cycle and pharmacoepigenetics
R Cacabelos, I Tellado, P Cacabelos - Pharmacoepigenetics, 2019 - Elsevier
Epigenetics is a discipline that studies potentially reversible heritable changes in gene
expression with no structural modifications in the DNA sequence. The epigenetic machinery …
expression with no structural modifications in the DNA sequence. The epigenetic machinery …
Pan-cancer methylated dysregulation of long non-coding RNAs reveals epigenetic biomarkers
N Zhao, M Guo, C Zhang, C Wang… - Frontiers in Cell and …, 2022 - frontiersin.org
Different cancer types not only have common characteristics but also have their own
characteristics respectively. The mechanism of these specific and common characteristics is …
characteristics respectively. The mechanism of these specific and common characteristics is …