Precise patterns of gene expression in metazoans are controlled by three classes of
regulatory elements: promoters, enhancers and boundary elements. During differentiation …

Recent progress in whole-genome map** and imaging technologies has enabled the
characterization of the spatial organization and folding of the genome in the nucleus. In …

Past studies offer contradictory claims for the role of genome organization in the regulation
of gene activity. Here, we show through high-resolution chromosome conformation analysis …

The Hi-C technique has been shown to be a promising method to detect structural variations
(SVs) in human genomes. However, algorithms that can use Hi-C data for a full-range SV …

The establishment of cell types during development requires precise interactions between
genes and distal regulatory sequences. We have a limited understanding of how these …

Mammalian fertilization begins with the fusion of two specialized gametes, followed by major
epigenetic remodeling leading to the formation of a totipotent embryo. During the …

Recent efforts have shown that structural variations (SVs) can disrupt three-dimensional
genome organization and induce enhancer hijacking, yet no computational tools exist to …

The relationship between chromatin organization and gene regulation remains unclear.
While disruption of chromatin domains and domain boundaries can lead to misexpression of …

Skates are cartilaginous fish whose body plan features enlarged wing-like pectoral fins,
enabling them to thrive in benthic environments,. However, the molecular underpinnings of …

Long non-coding RNAs (lncRNAs) can be important components in gene-regulatory
networks, but the exact nature and extent of their involvement in human Mendelian disease …