Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

Simple Summary Matrix stiffness is recognized as a critical factor in cancer progression.
Recent studies have shown that matrix stiffening is caused by the accumulation, contraction …

As our understanding of cancer cell biology progresses, it has become clear that tumors are
a heterogenous mixture of different cell populations, some of which contain so called …

Mechanical forces play critical roles in the function of living cells. However, the underlying
mechanisms of how forces influence nuclear events remain elusive. Here, we show that …

The success of next-generation androgen receptor (AR) pathway inhibitors, such as
abiraterone acetate and enzalutamide, in treating prostate cancer has been hampered by …

Highlights•Physical cues from the tumor microenvironment strongly affect cancer cell
behavior.•Novel techniques increasingly help to capture those cues in vitro.•Mechanisms for …

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

Cancer has been characterized as a genetic disease, associated with mutations that cause
pathological alterations of the cell cycle, adhesion, or invasive motility. Recently, the …

Tissue injury disrupts the mechanical homeostasis that underlies normal tissue architecture
and function. The failure to resolve injury and restore homeostasis gives rise to progressive …