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Peptidomics
Peptides are biopolymers, typically consisting of 2–50 amino acids. They are biologically
produced by the cellular ribosomal machinery or by non-ribosomal enzymes and …
produced by the cellular ribosomal machinery or by non-ribosomal enzymes and …
Informatics and computational methods in natural product drug discovery: a review and perspectives
The discovery of new pharmaceutical drugs is one of the preeminent tasks—scientifically,
economically, and socially—in biomedical research. Advances in informatics and …
economically, and socially—in biomedical research. Advances in informatics and …
In silico Approaches for the Design and Optimization of Interfering Peptides Against Protein–Protein Interactions
Large contact surfaces of protein–protein interactions (PPIs) remain to be an ongoing issue
in the discovery and design of small molecule modulators. Peptides are intrinsically capable …
in the discovery and design of small molecule modulators. Peptides are intrinsically capable …
Spider venom: components, modes of action, and novel strategies in transcriptomic and proteomic analyses
N Langenegger, W Nentwig, L Kuhn-Nentwig - Toxins, 2019 - mdpi.com
This review gives an overview on the development of research on spider venoms with a
focus on structure and function of venom components and techniques of analysis. Major …
focus on structure and function of venom components and techniques of analysis. Major …
Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene
Spiders are one of the most successful venomous animals, with more than 48,000 described
species. Most spider venoms are dominated by cysteine-rich peptides with a diverse range …
species. Most spider venoms are dominated by cysteine-rich peptides with a diverse range …
Spider conservation in Europe: a review
Despite their ecological importance and diversity, spiders (Arachnida: Araneae) are
underrepresented in conservation policies in comparison to other groups. We review all …
underrepresented in conservation policies in comparison to other groups. We review all …
Phylogeny of the orb‐weaving spider family Araneidae (Araneae: Araneoidea)
We present a new phylogeny of the spider family Araneidae based on five genes (28S, 18S,
COI, H3 and 16S) for 158 taxa, identified and mainly sequenced by us. This includes 25 …
COI, H3 and 16S) for 158 taxa, identified and mainly sequenced by us. This includes 25 …
[HTML][HTML] The role and future prospects of artificial intelligence algorithms in peptide drug development
Z Chen, R Wang, J Guo, X Wang - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Peptide medications have been more well-known in recent years due to their many benefits,
including low side effects, high biological activity, specificity, effectiveness, and so on. Over …
including low side effects, high biological activity, specificity, effectiveness, and so on. Over …
Convergent evolution of venom gland transcriptomes across Metazoa
Animals have repeatedly evolved specialized organs and anatomical structures to produce
and deliver a mixture of potent bioactive molecules to subdue prey or predators—venom …
and deliver a mixture of potent bioactive molecules to subdue prey or predators—venom …
[HTML][HTML] An expert-based assessment of global threats and conservation measures for spiders
Despite the prominent role of spiders in most ecosystems, these invertebrates are still
notably endangered as well as underrepresented in current conservation efforts. We sent a …
notably endangered as well as underrepresented in current conservation efforts. We sent a …