Peptidomics

R Hellinger, A Sigurdsson, W Wu… - Nature Reviews …, 2023 - nature.com
Peptides are biopolymers, typically consisting of 2–50 amino acids. They are biologically
produced by the cellular ribosomal machinery or by non-ribosomal enzymes and …

Informatics and computational methods in natural product drug discovery: a review and perspectives

JD Romano, NP Tatonetti - Frontiers in genetics, 2019 - frontiersin.org
The discovery of new pharmaceutical drugs is one of the preeminent tasks—scientifically,
economically, and socially—in biomedical research. Advances in informatics and …

In silico Approaches for the Design and Optimization of Interfering Peptides Against Protein–Protein Interactions

ZS Hashemi, M Zarei, MK Fath, M Ganji… - Frontiers in Molecular …, 2021 - frontiersin.org
Large contact surfaces of protein–protein interactions (PPIs) remain to be an ongoing issue
in the discovery and design of small molecule modulators. Peptides are intrinsically capable …

Spider venom: components, modes of action, and novel strategies in transcriptomic and proteomic analyses

N Langenegger, W Nentwig, L Kuhn-Nentwig - Toxins, 2019 - mdpi.com
This review gives an overview on the development of research on spider venoms with a
focus on structure and function of venom components and techniques of analysis. Major …

Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene

SS Pineda, YKY Chin, EAB Undheim, S Senff… - Proceedings of the …, 2020 - pnas.org
Spiders are one of the most successful venomous animals, with more than 48,000 described
species. Most spider venoms are dominated by cysteine-rich peptides with a diverse range …

Spider conservation in Europe: a review

F Milano, T Blick, P Cardoso, M Chatzaki… - Biological …, 2021 - Elsevier
Despite their ecological importance and diversity, spiders (Arachnida: Araneae) are
underrepresented in conservation policies in comparison to other groups. We review all …

Phylogeny of the orb‐weaving spider family Araneidae (Araneae: Araneoidea)

N Scharff, JA Coddington, TA Blackledge… - …, 2020 - Wiley Online Library
We present a new phylogeny of the spider family Araneidae based on five genes (28S, 18S,
COI, H3 and 16S) for 158 taxa, identified and mainly sequenced by us. This includes 25 …

[HTML][HTML] The role and future prospects of artificial intelligence algorithms in peptide drug development

Z Chen, R Wang, J Guo, X Wang - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Peptide medications have been more well-known in recent years due to their many benefits,
including low side effects, high biological activity, specificity, effectiveness, and so on. Over …

Convergent evolution of venom gland transcriptomes across Metazoa

G Zancolli, M Reijnders, RM Waterhouse… - Proceedings of the …, 2022 - pnas.org
Animals have repeatedly evolved specialized organs and anatomical structures to produce
and deliver a mixture of potent bioactive molecules to subdue prey or predators—venom …

[HTML][HTML] An expert-based assessment of global threats and conservation measures for spiders

VV Branco, P Cardoso - Global Ecology and Conservation, 2020 - Elsevier
Despite the prominent role of spiders in most ecosystems, these invertebrates are still
notably endangered as well as underrepresented in current conservation efforts. We sent a …