Brain development in humans is achieved through precise spatiotemporal genetic control,
the mechanisms of which remain largely elusive. Recently, integration of technological …

Organoids are systems derived from pluripotent stem cells at the interface between
traditional monolayer cultures and in vivo animal models. The structural and functional …

Studying the function of common genetic variants in primary human tissues and during
development is challenging. To address this, we use an efficient multiplexing strategy to …

Determining the causes of schizophrenia has been a notoriously intractable problem,
resistant to a multitude of investigative approaches over centuries. In recent decades …

The human nervous system is a remarkably complex physiological network that is inherently
challenging to study because of obstacles to acquiring primary samples. Animal models …

Background The first human brain organoid protocol was presented in the beginning of the
previous decade, and since then, the field witnessed the development of many new brain …

Importance Three-dimensional cerebral organoids generated from patient-derived induced
pluripotent stem cells (iPSCs) may be used to interrogate cellular-molecular underpinnings …

Human brain tissue models such as cerebral organoids are essential tools for
developmental and biomedical research. Current methods to generate cerebral organoids …

Exogenous administration of inflammatory stimuli to humans and laboratory animals and
chronic endogenous inflammatory states lead to motivational deficits and ultimately …

The derivation of human embryonic stem cells (hESCs) and the stunning discovery that
somatic cells can be reprogrammed into human induced pluripotent stem cells (hiPSCs) …