The biological applications of DNA nanomaterials: current challenges and future directions

W Ma, Y Zhan, Y Zhang, C Mao, X **e… - Signal transduction and …, 2021 - nature.com
DNA, a genetic material, has been employed in different scientific directions for various
biological applications as driven by DNA nanotechnology in the past decades, including …

Mobile genetic elements associated with antimicrobial resistance

SR Partridge, SM Kwong, N Firth… - Clinical microbiology …, 2018 - journals.asm.org
Strains of bacteria resistant to antibiotics, particularly those that are multiresistant, are an
increasing major health care problem around the world. It is now abundantly clear that both …

[HTML][HTML] Plasmid transfer by conjugation in Gram-negative bacteria: from the cellular to the community level

C Virolle, K Goldlust, S Djermoun, S Bigot, C Lesterlin - Genes, 2020 - mdpi.com
Bacterial conjugation, also referred to as bacterial sex, is a major horizontal gene transfer
mechanism through which DNA is transferred from a donor to a recipient bacterium by direct …

Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases

J Ferreira da Silva, CJ Tou, EM King, ML Eller… - Nature …, 2024 - nature.com
Genome editing technologies based on DNA-dependent polymerases (DDPs) could offer
several benefits compared with other types of editors to install diverse edits. Here, we …

Adenoviral vector-based vaccine platform for COVID-19: Current status

VP Chavda, R Bezbaruah, D Valu, B Patel, A Kumar… - Vaccines, 2023 - mdpi.com
The coronavirus disease (COVID-19) breakout had an unimaginable worldwide effect in the
21st century, claiming millions of lives and putting a huge burden on the global economy …

Landscape of mobile genetic elements and their antibiotic resistance cargo in prokaryotic genomes

S Khedkar, G Smyshlyaev, I Letunic… - Nucleic Acids …, 2022 - academic.oup.com
Abstract Prokaryotic Mobile Genetic Elements (MGEs) such as transposons, integrons,
phages and plasmids, play important roles in prokaryotic evolution and in the dispersal of …

SMART: recent updates, new developments and status in 2020

I Letunic, S Khedkar, P Bork - Nucleic acids research, 2021 - academic.oup.com
Abstract SMART (Simple Modular Architecture Research Tool) is a web resource
(https://smart. embl. de) for the identification and annotation of protein domains and the …

Origin of viruses: primordial replicators recruiting capsids from hosts

M Krupovic, VV Dolja, EV Koonin - Nature Reviews Microbiology, 2019 - nature.com
Viruses are ubiquitous parasites of cellular life and the most abundant biological entities on
Earth. It is widely accepted that viruses are polyphyletic, but a consensus scenario for their …

Transposon-encoded nucleases use guide RNAs to promote their selfish spread

C Meers, HC Le, SR Pesari, FT Hoffmann… - Nature, 2023 - nature.com
Insertion sequences are compact and pervasive transposable elements found in bacteria,
which encode only the genes necessary for their mobilization and maintenance. IS200-and …

[HTML][HTML] Origins and evolution of viruses of eukaryotes: the ultimate modularity

EV Koonin, VV Dolja, M Krupovic - Virology, 2015 - Elsevier
Viruses and other selfish genetic elements are dominant entities in the biosphere, with
respect to both physical abundance and genetic diversity. Various selfish elements …