The central nervous system responds to diverse neurologic injuries with a vigorous
activation of astrocytes. While this phenomenon is found in many different species, its …

For many decades, the inability of lesioned central neurons to regrow was accepted almost
as a" law of nature", and on the clinical level, spinal cord and brain lesions were seen as …

Reactive astrogliosis is characterized by a profound change in astrocyte phenotype in
response to all CNS injuries and diseases. To better understand the reactive astrocyte state …

Alzheimer's disease (AD) is characterized by the selective vulnerability of specific neuronal
populations, the molecular signatures of which are largely unknown. To identify and …

All cells sense and integrate mechanical and biochemical cues from their environment to
orchestrate organismal development and maintain tissue homeostasis …

Axonal regeneration in the lesioned mammalian central nervous system is abortive, and this
causes permanent disabilities in individuals with spinal cord injuries. In adult rats, olfactory …

Damage to the central nervous system (CNS) leads to cellular changes not only in the
affected neurons but also in adjacent glial cells and endothelia, and frequently, to a …

Post-traumatic cystic cavitation, in which the size and severity of a CNS injury progress from
a small area of direct trauma to a greatly enlarged secondary injury surrounded by glial scar …

The basic concept, that specialized extracellular matrices rich in hyaluronan, chondroitin
sulfate proteoglycans (aggrecan, versican, neurocan, brevican, phosphacan), link proteins …

We have recently reported that minimally disturbed adult CNS white matter can support
regeneration of adult axons by using a novel microtransplantation technique to inject minute …