Modifiable risk and protective factors for boosting brain and cognitive development and
preventing neurodegeneration and cognitive decline are embraced in neuroimaging …

As the global population faces a progressive shift towards a higher median age,
understanding the mechanisms underlying healthy brain ageing has become of paramount …

Higher educational attainment is observationally associated with lower risk of Alzheimer's
disease. However, the biological mechanisms underpinning this association remain unclear …

Older adults with lower education are at greater risk for dementia. It is unclear which brain
changes lead to these outcomes. Longitudinal imaging-based measures of brain structure …

Our understanding of human neurocognitive aging, its developmental roots, and life course
influences has been transformed by brain imaging technologies, increasing availability of …

Increased lifespan in the population was historically driven by reductions in infant mortality
but is now driven by reduced mortality in older adults. Research is beginning to show …

Biologically based senescence processes and cumulative opportunities for experience
collectively give rise to profound changes in cognition in later adulthood, the trajectories of …

Short sleep is held to cause poorer brain health, but is short sleep associated with higher
rates of brain structural decline? Analysing 8,153 longitudinal MRIs from 3,893 healthy …

Medial temporal lobe (MTL) atrophy is a key feature of Alzheimer's disease (AD), however, it
also occurs in typical aging. To enhance the clinical utility of this biomarker, we need to …

Despite major advances, our understanding of the neurobiology of life course
socioeconomic conditions is still scarce. This study aimed to provide insight into the …