The gut and the liver are characterized by mutual interactions between both organs, the
microbiome, diet and other environmental factors. The sum of these interactions is …

The innate immune system is the oldest protection strategy that is conserved across all
organisms. Although having an unspecific action, it is the first and fastest defense …

Generation of functionally mature organs requires exquisite control of transcriptional
programs governing cell state transitions during development. Despite advances in …

The mucosal immune system of neonates goes through successive, non-redundant phases
that support the developmental needs of the infant and ultimately establish immune …

Following birth, the neonatal intestine is exposed to maternal and environmental bacteria
that successively form a dense and highly dynamic intestinal microbiota. Whereas the effect …

Highlights•In utero microbial stimulation modulates both prenatal and postnatal immune cell
development.•Unique neonatal gut microenvironment allows for progressive colonization of …

Human gut development requires the orchestrated interaction of differentiating cell types.
Here, we generate an in-depth single-cell map of the develo** human intestine at 6–10 …

The intestine is a vital organ responsible for nutrient absorption, bile and waste excretion,
and a major site of host immunity. In order to keep up with daily demands, the intestine has …

The existence of a neonatal window was first highlighted by epidemiological studies that
revealed the particular importance of this early time in life for the susceptibility to immune …

Members of the Prdm family are characterized by an N-terminal PR domain that is related to
the SET methyltransferase domain, and multiple zinc fingers that mediate sequence-specific …