Over the years, many explanations have been put forward to explain early and late deaths
following hemorrhagic trauma. Most include single-event, sequential contributions from …

Globally, a staggering 310 million major surgeries are performed each year; around 40 to 50
million in USA and 20 million in Europe. It is estimated that 1–4% of these patients will die …

When a traumatic injury exceeds the body's internal tolerances, the innate immune and
inflammatory systems are rapidly activated, and if not contained early, increase morbidity …

BACKGROUND Assessment of the immediate need for specific blood product transfusions
in acutely bleeding patients is challenging. Clinical assessment and commonly used …

Severe burn injury elicits a profound stress response with the potential for high morbidity
and mortality. If polytrauma is present, patient outcomes appear to be worse. Sex-based …

Severe infection and sepsis are medical emergencies. High morbidity and mortality are
linked to CNS dysfunction, excessive inflammation, immune compromise, coagulopathy and …

Mitochondrial function is essential for bioenergetics, metabolism, and signaling and is
compromised in diseases such as proteinuric kidney diseases, contributing to the global …

If a trauma (or infection) exceeds the body's evolutionary design limits, a stress response is
activated to quickly restore homeostasis. However, when the injury severity score is high …

Background The trauma of surgery is a neglected area of research. Our aim was to examine
the differential expression of genes of stress, metabolism and inflammation in the major …

Introduction In multiple trauma patients, the occurrence of trauma-induced coagulopathy
(TIC) is closely associated with tissue damage and coagulation function abnormalities in the …