Microglia are resident immune cells in the brain and play a central role in the development
and surveillance of the nervous system. Extensive gliosis is a common pathological feature …

Background: Epigenetic alterations comprise key regulatory events that dynamically alter
gene expression and their deregulation is commonly linked to the pathogenesis of various …

Acute lung injury (ALI) is a pulmonary disorder that causes acute respiratory failure, thus
leading to relative high mortality worldwide. However, the molecular mechanisms of ALI …

Neurotoxic A1 reactive astrocytes are induced by inflammatory stimuli. Leptin has been
confirmed to have neuroprotective properties. However, its effect on the activation of A1 …

Sepsis, defined as a dysregulated host immune response to infection, is a common and
dangerous clinical syndrome. The excessive host inflammatory response can induce …

Mechanisms regulating neurogenesis involve broad and complex processes that represent
intriguing therapeutic targets in the field of regenerative medicine. One influential factor …

The quality of parental care received during development profoundly influences an
individual's phenotype, including that of maternal behavior. We previously found that female …

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers with an extremely
poor prognosis. Gemcitabine (Gem) is still the mainstay drug for the treatment of PDAC …

Many neural sex differences are differences in the number of neurons of a particular
phenotype. For example, male rodents have more calbindin-expressing neurons in the …

Early life encounters with stress can lead to long-lasting beneficial alterations in the
response to various stressors, known as cross-tolerance. Embryonic heat conditioning …