Integrin receptors are the main molecular link between cells and the extracellular matrix
(ECM) as well as mediating cell–cell interactions. Integrin–ECM binding triggers the …

Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

Cell migration is essential for many biological processes, while abnormal cell migration is
characteristic of cancer cells. Epithelial cells become motile by undergoing epithelial-to …

Bleb-based migration, a conserved cell motility mode, has a crucial role in both
physiological and pathological processes. Unlike the well-elucidated mechanisms of …

In crowded microenvironments, migrating cells must find or make a path. Amoeboid cells are
thought to find a path by deforming their bodies to squeeze through tight spaces. Yet, some …

Anoikis, known as matrix detachment-induced apoptosis or detachment-induced cell death,
is crucial for tissue development and homeostasis. Cancer cells develop means to evade …

Regulated cell death (RCD) plays a pivotal role in various biological processes, including
development, tissue homeostasis, and immune response. However, a comprehensive …

Apoptosis is the best described form of regulated cell death, and was, until relatively
recently, considered irreversible once particular biochemical points-of-no-return were …

Cell death is a fundamental physiological process in all living organisms. Processes such as
embryonic development, organ formation, tissue growth, organismal immunity, and drug …

Microfluidic chips are valuable tools for studying intricate cellular and cell–microenvironment
interactions. Traditional in vitro cancer models lack accuracy in mimicking the complexities …