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[HTML][HTML] Unique chemistry, intake, and metabolism of polyamines in the central nervous system (CNS) and its body
Polyamines (PAs) are small, versatile molecules with two or more nitrogen-containing
positively charged groups and provide widespread biological functions. Most of these …
positively charged groups and provide widespread biological functions. Most of these …
Organic cation transporters in psychiatric and substance use disorders
Psychiatric and substance use disorders inflict major public health burdens worldwide. Their
widespread burden is compounded by a dearth of effective treatments, underscoring a dire …
widespread burden is compounded by a dearth of effective treatments, underscoring a dire …
Several orphan solute carriers functionally identified as organic cation transporters: Substrates specificity compared with known cation transporters
Organic cations comprise a significant part of medically relevant drugs and endogenous
substances. Such substances need organic cation transporters for efficient transfer via cell …
substances. Such substances need organic cation transporters for efficient transfer via cell …
Interactions of calmodulin kinase II with the dopamine transporter facilitate cocaine-induced enhancement of evoked dopamine release
Typical and atypical dopamine uptake inhibitors (DUIs) prefer distinct conformations of the
dopamine transporter (DAT) to form ligand-transporter complexes, resulting in markedly …
dopamine transporter (DAT) to form ligand-transporter complexes, resulting in markedly …
Vesicular monoamine transporter (VMAT) regional expression and roles in pathological conditions
M Alwindi, A Bizanti - Heliyon, 2023 - cell.com
Vesicular monoamine transporters (VMATs) are key regulators of neurotransmitter release
responsible for controlling numerous physiological, cognitive, emotional, and behavioral …
responsible for controlling numerous physiological, cognitive, emotional, and behavioral …
Investigation on the positive chronotropic action of 6-nitrodopamine in the rat isolated atria
Nitrodopamine (6-ND) is released from rat isolated atria being 100 times more potent than
noradrenaline and adrenaline, and 10,000 times more potent than dopamine as a positive …
noradrenaline and adrenaline, and 10,000 times more potent than dopamine as a positive …
Bioisosteric analogs of MDMA: Improving the pharmacological profile?
Methylenedioxymethamphetamine (MDMA,'ecstasy') is re‐emerging in clinical settings as a
candidate for the treatment of specific neuropsychiatric disorders (eg post‐traumatic stress …
candidate for the treatment of specific neuropsychiatric disorders (eg post‐traumatic stress …
Interaction profiles of central nervous system active drugs at human organic cation transporters 1–3 and human plasma membrane monoamine transporter
Many psychoactive compounds have been shown to primarily interact with high-affinity and
low-capacity solute carrier 6 (SLC6) monoamine transporters for norepinephrine (NET; …
low-capacity solute carrier 6 (SLC6) monoamine transporters for norepinephrine (NET; …
Role of organic cation transporter 3 and plasma membrane monoamine transporter in the rewarding properties and locomotor sensitizing effects of amphetamine in …
A lack of effective treatment and sex-based disparities in psychostimulant addiction and
overdose warrant further investigation into mechanisms underlying the abuse-related effects …
overdose warrant further investigation into mechanisms underlying the abuse-related effects …
Organic Cation Transporters in Psychiatric Disorders
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed
medications for psychiatric disorders, yet they leave the majority of patients without full …
medications for psychiatric disorders, yet they leave the majority of patients without full …