Gene expression in bacteria relies on promoter recognition by the DNA-dependent RNA
polymerase and subsequent transcription initiation. Bacterial cells are able to tune their …

Small RNAs are ubiquitously present regulators in all kingdoms of life. Most bacterial and
archaeal small RNAs (sRNAs) act by antisense mechanisms on multiple target mRNAs …

Despite enormous progress in understanding the fundamentals of bacterial gene regulation,
our knowledge remains limited when compared with the number of bacterial genomes and …

Transcription-coupled DNA repair (TCR) is presumed to be a minor sub-pathway of
nucleotide excision repair (NER) in bacteria. Global genomic repair is thought to perform the …

RNA offers nearly unlimited potential as a target for small molecule chemical probes and
lead medicines. Many RNAs fold into structures that can be selectively targeted with small …

Advances in transcriptome sequencing allow for simultaneous interrogation of differentially
expressed genes from multiple species originating from a single RNA sample, termed dual …

Staphylococcus aureus is a major pathogen that colonizes about 20% of the human
population. Intriguingly, this Gram-positive bacterium can survive and thrive under a wide …

How new functions arise de novo is a fundamental question in evolution. We studied de
novo evolution of promoters in Escherichia coli by replacing the lac promoter with various …

In eukaryotes, mechanisms such as alternative splicing (AS) and alternative translation
initiation (ATI) contribute to organismal protein diversity. Specifically, splicing factors play …

At the end of the multistep transcription process, the elongating RNA polymerase (RNAP) is
dislodged from the DNA template either at specific DNA sequences, called the terminators …