The complex bidirectional communication between the gut and the brain is finely
orchestrated by different systems, including the endocrine, immune, autonomic, and enteric …

Given that obesity and associated disorder type II diabetes mellitus have reached epidemic
proportions worldwide, the development of efficient prevention and therapeutic interventions …

Microglia-mediated neuroinflammation plays a crucial role in the pathophysiological process
of multiple neurological disorders such as ischemic stroke, yet lacks effective therapeutic …

It has been more than 36 years since peroxisome proliferator-activated receptors (PPARs)
were first recognized as enhancers of peroxisome proliferation. Consequently, many studies …

Metabolic diseases such as obesity, type 2 diabetes mellitus, and hyperlipidemia are
associated with the dysfunction of gut microbiota. Traditional Chinese medicines (TCMs) …

As technologies used to study the gut microbiota have improved, the relationship between
the gut microbiota and health has become increasingly obvious. Herbal medicines have …

The incidence of obesity and colorectal cancer (CRC) has risen rapidly in recent decades.
More than 650 million obese and 2 billion overweight individuals are currently living in the …

Capsaicin, the major active constituent of chilli, is an agonist on transient receptor potential
vanilloid channel 1 (TRPV1). TRPV1 is present on many metabolically active tissues …

Background Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease
with an increasing incidence worldwide. Single drug therapy may have toxic side effects and …

Misalignment between natural light rhythm and modern life activities induces disruption of
the circadian rhythm. It is mainly evident that light at night (LAN) interferes with the human …