Mitochondria are believed to have originated through an ancient endosymbiotic process in
which proteobacteria were captured and co-opted for energy production and cellular …

With the increasing research and deepening understanding of the glioblastoma (GBM)
tumour microenvironment (TME), novel and more effective therapeutic strategies have been …

The blood-brain barrier (BBB) acts as the crucial physical filtration structure in the central
nervous system. Here, we investigate the role of a specific subset of astrocytes in the …

Low-grade glioma (LGG) is a grade II-III glioma accompanied by distinct clinical and
molecular characteristics and the studies related to its prognosis are still unclear. The …

Glioblastoma (GBM) is characterized by heterogeneous malignant cells that are functionally
integrated within the neuroglial microenvironment. In this study, we model this ecosystem by …

Ovarian cancer is characterized by early metastatic spread. This study demonstrates that
carcinoma-associated mesenchymal stromal cells (CA-MSCs) enhance metastasis by …

Immunotherapy is regarded as one of the most promising approaches for treating tumors,
with a multitude of immunotherapeutic thoughts currently under consideration for the lethal …

Intercellular signaling and component conduction are essential for multicellular organisms'
homeostasis, and mitochondrial transcellular transport is a key example of such cellular …

Otto Warburg hypothesized that some cancer cells reprogram their metabolism, favoring
glucose metabolism by anaerobic glycolysis (Warburg effect) instead of oxidative …

The Swiss cheese model is used to assess risks and explain accidents in a variety of
industries. This model can be applied to dissect the homeostatic mechanisms whose …