Grand challenges for industrializing polyhydroxyalkanoates (PHAs)

D Tan, Y Wang, Y Tong, GQ Chen - Trends in biotechnology, 2021 - cell.com
Polyhydroxyalkanoates (PHAs) are a diverse family of sustainable bioplastics synthesized
by various bacteria, but their high production cost and unstable material properties make …

Escherichia coli as a host for metabolic engineering

S Pontrelli, TY Chiu, EI Lan, FYH Chen, P Chang… - Metabolic …, 2018 - Elsevier
Over the past century, Escherichia coli has become one of the best studied organisms on
earth. Features such as genetic tractability, favorable growth conditions, well characterized …

Next generation industrial biotechnology based on extremophilic bacteria

GQ Chen, XR Jiang - Current opinion in biotechnology, 2018 - Elsevier
Highlights•Low petroleum prices require innovations to make bio-production competitive.•
Contamination resistant extremophilic microorganisms can simplify bioprocessing.•Next …

Physiological limitations and opportunities in microbial metabolic engineering

J Montaño López, L Duran, JL Avalos - Nature Reviews Microbiology, 2022 - nature.com
Metabolic engineering can have a pivotal role in increasing the environmental sustainability
of the transportation and chemical manufacturing sectors. The field has already developed …

Synthetic biology of extremophiles: a new wave of biomanufacturing

JW Ye, YN Lin, XQ Yi, ZX Yu, X Liu, GQ Chen - Trends in Biotechnology, 2023 - cell.com
Microbial biomanufacturing, powered by the advances of synthetic biology, has attracted
growing interest for the production of diverse products. In contrast to conventional microbes …

Bacillus genus industrial applications and innovation: First steps towards a circular bioeconomy

LW Herrmann, LAJ Letti, R de Oliveira Penha… - Biotechnology …, 2024 - Elsevier
In recent decades, environmental concerns have directed several policies, investments, and
production processes. The search for sustainable and eco-friendly strategies is constantly …

Potential applications of extremophilic bacteria in the bioremediation of extreme environments contaminated with heavy metals

J Sun, X He, LE Yilin, R Al-Tohamy, SS Ali - Journal of Environmental …, 2024 - Elsevier
Protecting the environment from harmful pollutants has become increasingly difficult in
recent decades. The presence of heavy metal (HM) pollution poses a serious environmental …

Next‐generation industrial biotechnology‐transforming the current industrial biotechnology into competitive processes

LP Yu, FQ Wu, GQ Chen - Biotechnology Journal, 2019 - Wiley Online Library
The chemical industry has made a contribution to modern society by providing cost‐
competitive products for our daily use. However, it now faces a serious challenge regarding …

Combined effects of concentration, pH, and polycrystalline copper surfaces on electrocatalytic nitrate-to-ammonia activity and selectivity

L Barrera, R Silcox, K Giammalvo, E Brower, E Isip… - ACS …, 2023 - ACS Publications
Wastewater nitrates (NO3–) represent an untapped source for nutrient recovery. This study
explores the effects of NO3–concentration ranging from 0.1 to 1 M and pH conditions of 8 …

Engineering microorganisms for improving polyhydroxyalkanoate biosynthesis

GQ Chen, XR Jiang - Current opinion in biotechnology, 2018 - Elsevier
Highlights•Improvements on PHA biosynthesis must be considered in a systematic
way.•Directing metabolic flux to PHA synthesis is critical for improving conversion …