Etoposide is an important chemotherapeutic agent that is used to treat a wide spectrum of
human cancers. It has been in clinical use for more than two decades and remains one of …

Topoisomerase II is a ubiquitous enzyme that is essential for the survival of all eukaryotic
organisms and plays critical roles in virtually every aspect of DNA metabolism. The enzyme …

Abstract Objectives Doxorubicin (Dox) belongs to the anthracycline drug classification and is
a widely administered chemotherapeutic. However, Dox use in therapy is limited by its …

Although the one-dimensional sequence of DNA determines the genetic constitution of an
organism, topological relationships within the double helix modulate virtually every …

The major established cause of acute myeloid leukemia (AML) in the young is cancer
chemotherapy. There are two forms of treatment-related AML (t-AML). Each form has a de …

INTRODUCTION The faithful replication and segregation of chromosomes as part of the cell
division cycle requires that topological changes be imposed upon cellular DNA …

The alkylating agents are antitumor drugs that act through the covalent binding of alkyl
groups to cellular molecules. This binding is mediated by reactive intermediates formed from …

Therapy-related leukemia (myelodysplasia and acute myeloid leukemia—t-MDS/AML) is a
well-known complication of conventional chemoradiotherapy used to treat a variety of …

Topoisomerase 11 is an essential enzyme that plays a role in virtually every cellular DNA
process. This enzyme interconverts different topological forms of DNA by passing one …

Merbarone is a catalytic inhibitor of topoisomerase II that is in clinical trials as an anticancer
agent. Despite the potential therapeutic value of this drug, the mechanism by which it blocks …