Late-stage functionalization (LSF) introduces functional group or structural modification at
the final stage of the synthesis of natural products, drugs, and complex compounds. It is …

C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with
notable applications to material sciences, crop protection, drug discovery, and …

Over the past few decades, the advent of C–H activation has led to a rethink among
chemists about the synthetic strategies employed for multi-step transformations. Indeed …

Cross-coupling reactions, which were discovered almost 50 years ago, are widely used in
both industry and academia. Even though cross-coupling reactions now represent mature …

Conspectus Transition-metal-catalyzed cross-coupling reactions represent a most powerful
tool for the rapid construction of C–C and C–X bonds available to synthetic chemists …

Photoredox catalysis has experienced a revitalized interest from the synthesis community
during the past decade. For example, photoredox/Ni dual catalysis protocols have been …

Catalytic cross-coupling reactions of aromatic esters and amides have recently gained
considerable attention from synthetic chemists as de novo and efficient synthetic methods to …

Tremendous advances have been made in nickel catalysis over the past decade. Several
key properties of nickel, such as facile oxidative addition and ready access to multiple …

An iridium photocatalyst and visible light facilitate a room temperature, nickel-catalyzed
coupling of (hetero) aryl bromides with activated α-heterosubstituted or benzylic C (sp3)–H …

Transition metal-catalysed cross-coupling is one of the most powerful synthetic methods and
has led to vast improvements in the synthesis of pharmaceuticals, agrochemicals and …