Role of endothelial shear stress in stent restenosis and thrombosis: pathophysiologic mechanisms and implications for clinical translation

KC Koskinas, YS Chatzizisis, AP Antoniadis… - Journal of the American …, 2012 - jacc.org
Restenosis and thrombosis are potentially fatal complications of coronary stenting with a
recognized multifactorial etiology. The effect of documented risk factors, however, cannot …

[HTML][HTML] The road to the ideal stent: A review of stent design optimisation methods, findings, and opportunities

A Kapoor, N Jepson, NW Bressloff, PH Loh, T Ray… - Materials & Design, 2024 - Elsevier
Coronary stent designs have undergone significant transformations in geometry, materials,
and drug elution coatings, contributing to the continuous improvement of stenting success …

Assessment of CFD performance in simulations of an idealized medical device: results of FDA's first computational interlaboratory study

SFC Stewart, EG Paterson, GW Burgreen… - Cardiovascular …, 2012 - Springer
While computational fluid dynamics (CFD) is commonly used for medical device
development, its usefulness for demonstrating device safety has not been proven. Reliable …

Effect of the endothelial shear stress patterns on neointimal proliferation following drug-eluting bioresorbable vascular scaffold implantation: an optical coherence …

CV Bourantas, MI Papafaklis, A Kotsia, V Farooq… - JACC: Cardiovascular …, 2014 - jacc.org
Objectives: This study sought to investigate the effect of endothelial shear stress (ESS) on
neointimal formation following an Absorb bioresorbable vascular scaffold (BVS)(Abbott …

Stents: biomechanics, biomaterials, and insights from computational modeling

GS Karanasiou, MI Papafaklis, C Conway… - Annals of biomedical …, 2017 - Springer
Coronary stents have revolutionized the treatment of coronary artery disease. Improvement
in clinical outcomes requires detailed evaluation of the performance of stent biomechanics …

Advances in nitric oxide-releasing hydrogels for biomedical applications

LME Bright, Y Wu, EJ Brisbois, H Handa - Current opinion in colloid & …, 2023 - Elsevier
Hydrogels provide a plethora of advantages to biomedical treatments due to their highly
hydrophilic nature and tissue-like mechanical properties. Additionally, the numerous and …

Multiobjective design optimisation of coronary stents

S Pant, G Limbert, NP Curzen, NW Bressloff - Biomaterials, 2011 - Elsevier
We present here a multi-objective and multi-disciplinary coronary stent design optimization
paradigm. Coronary stents are tubular, often mesh-like, structures which are deployed in …

Hemodynamics in idealized stented coronary arteries: important stent design considerations

S Beier, J Ormiston, M Webster, J Cater… - Annals of biomedical …, 2016 - Springer
Stent induced hemodynamic changes in the coronary arteries are associated with higher
risk of adverse clinical outcome. The purpose of this study was to evaluate the impact of …

On the necessity of modelling fluid–structure interaction for stented coronary arteries

C Chiastra, F Migliavacca, MÁ Martínez… - Journal of the mechanical …, 2014 - Elsevier
Although stenting is the most commonly performed procedure for the treatment of coronary
atherosclerotic lesions, in-stent restenosis (ISR) remains one of the most serious clinical …

Structural and hemodynamic analyses of different stent structures in curved and stenotic coronary artery

L Wei, HL Leo, Q Chen, Z Li - Frontiers in bioengineering and …, 2019 - frontiersin.org
Coronary artery stenting is commonly used for the treatment of coronary stenosis, and
different stent structures indeed have various impacts on the stress distribution within the …