Due to its relatively easy synthesis, isoxazole ring has been as an object of interest for
chemists and pharmacologists from research groups all over the world. Its chemical …

Isoxazole, constituting an important family of five-membered heterocycles with one oxygen
atom and one nitrogen atom at adjacent positions is of immense importance because of its …

Nile red and Nile blue are highly fluorescent and photostable organic dyes from the benzo
[a] phenoxazine family. They have been used as histological stains for imaging lysosomes …

Coumarins are natural products characterized as 1, 2 benzopyrones widely distributed in
plants, as well as, in many species of fungi and bacteria. Nowadays, many synthetic …

COX-2, a key enzyme that catalyzed the rate-limiting steps in the conversion of arachidonic
acid to prostaglandins, played a pivotal role in the inflammatory process. Different from other …

The beneficial effects of Cyclooxygenases (COX) inhibitors on human health have been
known for thousands of years. Nevertheless, COXs, particularly COX-1, have been linked to …

Abstract Cyclooxygenase 2 (COX-2) and the production of cytokines/chemokines are
important targets for the modulation of the inflammatory response. Although a large variety of …

Novel series of celecoxib analogs endowed with benzofuran moiety 3a–e and 9a–d were
synthesized and evaluated for COX-1/COX-2 inhibitory activity in vitro. The most potent and …

Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of molecules which have been
found to be active against cancer cells with chemopreventive properties by targeting …

The diarylisoxazole molecular scaffold is found in several NSAIDs, especially those with
high selectivity for COX-1. Here, we have determined the structural basis for COX-1 binding …