Persistent inflammatory and non-inflammatory mechanisms in refractory rheumatoid arthritis

MH Buch, S Eyre, D McGonagle - Nature Reviews Rheumatology, 2021 - nature.com
Despite nearly three decades of advances in the management of rheumatoid arthritis (RA), a
substantial minority of patients are exposed to multiple DMARDs without necessarily …

Fatigue in inflammatory rheumatic diseases: current knowledge and areas for future research

K Davies, E Dures, WF Ng - Nature Reviews Rheumatology, 2021 - nature.com
Fatigue is a complex phenomenon and an important health concern for many people with
chronic inflammatory rheumatic diseases, such as rheumatoid arthritis, psoriatic arthritis …

Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis

Z Bai, N Bartelo, M Aslam, EA Murphy… - Science Translational …, 2024 - science.org
It has been presumed that rheumatoid arthritis (RA) joint pain is related to inflammation in
the synovium; however, recent studies reveal that pain scores in patients do not correlate …

Society for Immunotherapy of Cancer (SITC) consensus definitions for immune checkpoint inhibitor-associated immune-related adverse events (irAEs) terminology

J Naidoo, C Murphy, MB Atkins… - Journal for …, 2023 - pmc.ncbi.nlm.nih.gov
Immune-related adverse events (irAEs) associated with immune checkpoint inhibitor (ICI)
therapy may vary substantially in their clinical presentation, including natural history …

The many facets of macrophages in rheumatoid arthritis

E Siouti, E Andreakos - Biochemical pharmacology, 2019 - Elsevier
Macrophages are central to the pathophysiology of rheumatoid arthritis (RA). They constitute
the main source of pro-inflammatory cytokines and chemokines such as TNF and IL-1β, they …

Affective disturbance in rheumatoid arthritis: psychological and disease-related pathways

JA Sturgeon, PH Finan, AJ Zautra - Nature Reviews Rheumatology, 2016 - nature.com
In addition to recurrent pain, fatigue, and increased rates of physical disability, individuals
with rheumatoid arthritis (RA) have an increased prevalence of some mental health …

Understanding the role of interleukin-6 (IL-6) in the joint and beyond: a comprehensive review of IL-6 inhibition for the management of rheumatoid arthritis

EG Favalli - Rheumatology and therapy, 2020 - Springer
Rheumatoid arthritis (RA) is a chronic, debilitating autoimmune disorder involving
inflammation and progressive destruction of the joints, affecting up to 1% of the population …

Measures of fatigue: Bristol rheumatoid arthritis fatigue multi‐dimensional questionnaire (BRAF MDQ), Bristol rheumatoid arthritis fatigue numerical rating scales …

S Hewlett, E Dures, C Almeida - Arthritis care & research, 2011 - Wiley Online Library
Fatigue is common to all the rheumatic conditions, in varying degrees, and is a frequent,
often severe problem that has major consequences on patients' lives (1–4). In response to …

Fatigue in chronic inflammation-a link to pain pathways

K Louati, F Berenbaum - Arthritis research & therapy, 2015 - Springer
Fatigue is a frequent symptom in several inflammatory diseases, particularly in rheumatic
diseases. Elements of disease activity and cognitive and behavior aspects have been …

Management of fatigue in rheumatoid arthritis

JE Pope - RMD open, 2020 - rmdopen.bmj.com
Fatigue in rheumatoid arthritis is highly prevalent. It is correlated only weakly with disease
activity but more so with pain, mood, personality features, poor sleep, obesity and …