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Fc-optimized anti-CCR8 antibody depletes regulatory T cells in human tumor models
JR Campbell, BR McDonald, PB Mesko… - Cancer …, 2021 - aacrjournals.org
FOXP3+ regulatory T cells (Treg) play a critical role in mediating tolerance to self-antigens
and can repress antitumor immunity through multiple mechanisms. Therefore, targeted …
and can repress antitumor immunity through multiple mechanisms. Therefore, targeted …
Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy
H Van Damme, B Dombrecht, M Kiss… - Journal for …, 2021 - pmc.ncbi.nlm.nih.gov
Background Modulation and depletion strategies of regulatory T cells (Tregs) constitute valid
approaches in antitumor immunotherapy but suffer from severe adverse effects due to their …
approaches in antitumor immunotherapy but suffer from severe adverse effects due to their …
Guidance factors orchestrating regulatory T cell positioning in tissues during development, homeostasis, and response
Over their lifetime, regulatory T cells (Treg) recalibrate their expression of trafficking
receptors multiple times as they progress through development, respond to immune …
receptors multiple times as they progress through development, respond to immune …
Basic interactions responsible for thymus function explain convoluted medulla shape
The thymus is one of the most important organs of the immune system. It is responsible for
both the production of T cells and the prevention of their autoimmunity. It comprises two …
both the production of T cells and the prevention of their autoimmunity. It comprises two …
Anti-CCR8 antibodies and uses thereof
PM Holland, A Lake, A Dulak, E Smith… - US Patent …, 2024 - Google Patents
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[C@@](O)(CC= 2C (O)= C3C (= O) C= 4C= CC= C (C= 4C (= O) C3= C (O) C= 21) OC) C …