New frontiers in immune checkpoint B7-H3 (CD276) research and drug development
Abstract B7-H3 (CD276), a member of the B7 family of proteins, is a key player in cancer
progression. This immune checkpoint molecule is selectively expressed in both tumor cells …
progression. This immune checkpoint molecule is selectively expressed in both tumor cells …
Wnt signaling in cancer
Wnt signaling is one of the key cascades regulating development and stemness, and has
also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has …
also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has …
RNA demethylase ALKBH5 selectively promotes tumorigenesis and cancer stem cell self-renewal in acute myeloid leukemia
Summary N 6-methyladenosine (m 6 A), the most abundant internal modification in mRNA,
has been implicated in tumorigenesis. As an m 6 A demethylase, ALKBH5 has been shown …
has been implicated in tumorigenesis. As an m 6 A demethylase, ALKBH5 has been shown …
The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions
We present the molecular landscape of pediatric acute myeloid leukemia (AML) and
characterize nearly 1,000 participants in Children's Oncology Group (COG) AML trials. The …
characterize nearly 1,000 participants in Children's Oncology Group (COG) AML trials. The …
Zebrafish as tools for drug discovery
The zebrafish has become a prominent vertebrate model for disease and has already
contributed to several examples of successful phenotype-based drug discovery. For the …
contributed to several examples of successful phenotype-based drug discovery. For the …
Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion
Little is known about how leukemia cells alter the bone marrow (BM) niche to facilitate their
own growth and evade chemotherapy. Here, we provide evidence that acute myeloid …
own growth and evade chemotherapy. Here, we provide evidence that acute myeloid …
Therapy-related myeloid neoplasms: when genetics and environment collide
Therapy-related myeloid neoplasms (t-MN) arise as a late effect of chemotherapy and/or
radiation administered for a primary condition, typically a malignant disease, solid organ …
radiation administered for a primary condition, typically a malignant disease, solid organ …
The Wnt signaling pathway in cancer
The Wnt signaling pathway is critically involved in both the development and homeostasis of
tissues via regulation of their endogenous stem cells. Aberrant Wnt signaling has been …
tissues via regulation of their endogenous stem cells. Aberrant Wnt signaling has been …
A critical role of nuclear m6A reader YTHDC1 in leukemogenesis by regulating MCM complex–mediated DNA replication
YTHDC1 has distinct functions as a nuclear N 6-methyladenosine (m6A) reader in
regulating RNA metabolism. Here we show that YTHDC1 is overexpressed in acute myeloid …
regulating RNA metabolism. Here we show that YTHDC1 is overexpressed in acute myeloid …
WNT signaling in tumors: the way to evade drugs and immunity
WNT/β-catenin signaling is involved in many physiological processes. Its implication in
embryonic development, cell migration, and polarization has been shown. Nevertheless …
embryonic development, cell migration, and polarization has been shown. Nevertheless …