Heat shock proteins (Hsps) have been studied for many years and there is now a large body
of evidence that demonstrates the role of Hsp upregulation in tissue and cell protection in a …

Neuronal cell death plays a role in many chronic neurodegenerative diseases with the loss
of particular subsets of neurons. The loss of the neurons occurs during a period of many …

Cerebral ischemia/reperfusion (I/R) injury triggers multiple and distinct but overlap** cell
signaling pathways, which may lead to cell survival or cell damage. There is overwhelming …

Neuroinflammation is a hallmark of ischemic stroke, which is a leading cause of death and
long‐term disability. Understanding the exact cellular signaling pathways that initiate and …

Although heat shock proteins have been studied for decades, new intracellular and
extracellular functions in a variety of diseases continue to be discovered. Heat shock …

HSP70 is a member of the family of heat‐shock proteins that are known to be up‐regulated
in neurons following injury and/or stress. HSP70 over‐expression has been linked to …

Modulation of endogenous cellular defense mechanisms via the stress response signaling
represents an innovative approach to therapeutic intervention in diseases causing chronic …

Heat shock protein 27 (Hsp27), a recently discovered member of the heat shock protein
family, is markedly induced in the brain after cerebral ischemia and other injury states. In …

This study examined the effect of TLR2 activation by its specific ligand, Pam3CSK4, on
cerebral ischemia/reperfusion (I/R) injury. Mice (n= 8/group) were treated with Pam3CSK4 1 …

MicroRNAs (miRNAs) have emerged as a major regulator in neurological diseases, and
understanding their molecular mechanism in modulating cerebral ischemic injury may …