Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis

W Chen, M Schilperoort, Y Cao, J Shi, I Tabas… - Nature Reviews …, 2022 - nature.com
Nanotechnology could improve our understanding of the pathophysiology of atherosclerosis
and contribute to the development of novel diagnostic and therapeutic strategies to further …

Nanogels: Synthesis, properties, and recent biomedical applications

QY Duan, YX Zhu, HR Jia, SH Wang, FG Wu - Progress in Materials …, 2023 - Elsevier
Nanogels, also termed hydrogel nanoparticles, have the properties and functions of both
nanomaterials and hydrogels. Till date, a considerable number of nanogels have been …

Applications of nanoparticles in biomedical imaging

X Han, K Xu, O Taratula, K Farsad - Nanoscale, 2019 - pubs.rsc.org
An urgent need for early detection and diagnosis of diseases continuously pushes the
advancements of imaging modalities and contrast agents. Current challenges remain for fast …

Brief update on endocytosis of nanomedicines

S Patel, J Kim, M Herrera, A Mukherjee… - Advanced drug delivery …, 2019 - Elsevier
The complexity of nanoscale interactions between biomaterials and cells has limited the
realization of the ultimate vision of nanotechnology in diagnostics and therapeutics. As such …

Dysfunctional HDL and atherosclerotic cardiovascular disease

RS Rosenson, HB Brewer Jr, BJ Ansell… - Nature reviews …, 2016 - nature.com
High-density lipoproteins (HDLs) protect against atherosclerosis by removing excess
cholesterol from macrophages through the ATP-binding cassette transporter A1 (ABCA1) …

Recommendation on design, execution, and reporting of animal atherosclerosis studies: a scientific statement from the American Heart Association

A Daugherty, AR Tall, MJAP Daemen… - … , and vascular biology, 2017 - Am Heart Assoc
Animal studies are a foundation for defining mechanisms of atherosclerosis and potential
targets of drugs to prevent lesion development or reverse the disease. In the current …

Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota

SR Ma, Q Tong, Y Lin, LB Pan, J Fu, R Peng… - Signal transduction and …, 2022 - nature.com
Abstract Trimethylamine-N-oxide (TMAO) derived from the gut microbiota is an atherogenic
metabolite. This study investigates whether or not berberine (BBR) could reduce TMAO …

Polymeric nanostructures for imaging and therapy

M Elsabahy, GS Heo, SM Lim, G Sun… - Chemical …, 2015 - ACS Publications
Medical diagnosis and therapy are essential for providing patients with proper care,
although inefficient diagnosis and therapy are usually associated with either improper …

Recent advances and future prospects of iron oxide nanoparticles in biomedicine and diagnostics

NVS Vallabani, S Singh - 3 Biotech, 2018 - Springer
Superparamagnetic iron oxide nanoparticles (SPIONs) are considered as chemically inert
materials and, therefore, being extensively applied in the areas of imaging, targeting, drug …

Anti-atherosclerotic therapies: milestones, challenges, and emerging innovations

I Hetherington, H Totary-Jain - Molecular Therapy, 2022 - cell.com
Atherosclerosis is the main underlying pathology for many cardiovascular diseases (CVDs),
which are the leading cause of death globally and represent a serious health crisis …