Mitochondria perform crucial functions in cellular metabolism, protein and lipid biogenesis,
quality control, and signaling. The systematic analysis of protein complexes and interaction …

In eukaryotic cells, mitochondria perform cellular respiration through a series of redox
reactions ultimately reducing molecular oxygen to water. The system responsible for this …

While reactive oxygen species (ROS) have long been known to drive aging and
neurodegeneration, their persistent depletion below basal levels also disrupts organismal …

Abstract Background Cardiovascular diseases (CVDs) are the leading cause of death
worldwide, and the prevalence of CVDs increases markedly with age. Due to the high …

Hepatic steatosis is the result of imbalanced nutrient delivery and metabolism in the liver
and is the first hallmark of Metabolic dysfunction-associated steatotic liver disease (MASLD) …

TIMM50 is a core subunit of the TIM23 complex, the mitochondrial inner membrane
translocase responsible for the import of pre-sequence-containing precursors into the …

Human cytochrome c oxidase (COX) is composed of fourteen subunits, only two of which are
catalytic. The functions of a myriad of accessory factors are needed to put together the …

Metabolic dysfunction associated steatotic liver disease (MASLD) is a worldwide problem,
affecting more than 20% of the population. As poor diet and sedentary lifestyles become …

Mitochondrial protein import is a complex process governing the delivery of the organelle's
proteome. This process, in turn, is essential for maintaining mitochondrial function and …

Mammalian F1Fo ATP synthase plays a crucial role in ATP production through the process
of oxidative phosphorylation. Assembly of this multisubunit protein complex requires specific …