Parkinson's disease (PD) is a multisystem alpha-synucleinopathic neurodegenerative
disease and the most prevalent neurodegenerative disorder after Alzheimer's disease with a …

The increasing number of MRI studies focused on prodromal Parkinson's Disease (PD)
demonstrates a strong interest in identifying early biomarkers capable of monitoring …

Background Brain glymphatic dysfunction may contribute to the development of α-
synucleinopathies. Yet, noninvasive imaging and quantification remain lacking. Purpose To …

Objectives This study aimed to evaluate glymphatic‐system function in patients with isolated
rapid eye movement sleep behavior disorder (iRBD) in comparison with healthy controls by …

Introduction Growing evidence has demonstrated dysfunction of the glymphatic system in α-
synucleinopathy and related diseases. In this study, we aimed to use diffusion tensor image …

Dysfunction of the glymphatic system, an intracranial clearance pathway that drains
misfolded proteins, has been implicated in the onset of Parkinson's disease (PD). Recently …

Sleep disorders affect many people worldwide and can accompany neurodegenerative and
psychiatric diseases. Sleep may be altered before the clinical manifestations of some of …

Poor sleep quality might contribute to the risk and progression of neurodegenerative
disorders via deficient cerebral waste clearance functions during sleep. In this retrospective …

The glymphatic system plays a crucial role in clearing metabolic wastes in the brain.
Glymphatic MR imaging using GBCA administration serves as a functional imaging tool to …

Sleep has been hypothesised to facilitate waste clearance from the brain. We aimed to
determine whether sleep is associated with perivascular spaces on brain magnetic …